Lavrenko A. V., Rasin M. S., Borzich O. A., Degtjar N. I., Gerasimenko N. D.

CONTENTS

Scentific article

Over the past 10-15 years, found that the major chronic diseases: atherosclerosis, many forms of cancer, chronic obstructive pulmonary disease, and other are associated with chronic systemic inflammation of low intensity (LGI). LGI is different from acute local inflammation have relatively small increase in circulating levels of cy- tokines (2-4 times) and have persistent course. Currently installed many molecular mechanisms of implementation of LGI in specific pathological processes. Based on these studies, making use of pharmacological prophylaxis and treatment of diseases associated with LGI. One important achievement is the understanding of the role of muscle tissue, the lack of activity which is one of the main reasons LGI, and physical training is the most important and promising method for the prevention of these diseases. The aim of this work is to analyze the influence of physical exercise on the level of inflammatory cytokines in patients with ischemic heart disease and obesity. Material and methods. We analyzed the level of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1. 6 and 8 by ELISA in 55 ambulatory patients with obesity (body mass index 36 ± 1,0), 1-2 effort angina functional class, hypertension and dyslipidemia atherogenic type, 55,6 ± 1,2 years. All patients were impaired carbohydrate metabo- lism in 27 diagnosed with type 2 diabetes in an easy manner. After screening patients proposed change lifestyle and engage in regular physical exercise of their choice, diet, close to the Mediterranean. and take the standard complex therapy. After 1 month, the patients were divided into 2 groups according to the declared degree increase physical activity, which we have characterized as “active” (when patients at least 30 minutes 3-4 times a week exercise) and “passive” – in the absence of follow recommendations. For comparison, patients were selected pair, are identical in all the studied parameters except the level of physical activity. Statistical processing was carried out by pairwise related option of using Student’s t test Results and discussion. It should be noted that for various reasons the compliance was not sufficient and only 12 patients adequately used recommendations. Nevertheless, we found a clear tendency to reduce systemic inflam- mation in conditions of increased physical activity. There are a large number of studies showing a decrease in physi- cal training HSV. Body mass index and smoking are important factors. In Greek ATTICA study found that circulating levels of proinflammatory cytokines reduced by persons engaged in physical exercise, compared with sedentary, including healthy young people Analyzed the levels of inflammatory cytokines: tumor necrosis factor -alpha (TNF-α), interleukin (IL) -1. 6 and 8,with the enzyme immunoassay in 55 ambulatory patients with obesity (body mass index 36 ± 1,0), 1-2 functional class angina pectoris, hypertension and dyslipidemia of atherogenic type, 55,6 ± 1,2 years. A clear downward trend in the level of LGI in conditions of increased physical activity. Based on the data concluded that working skeletal muscle is an endocrine organ, producing myokines providing anti-inflammatory effect that reduces insulin resistens and acting as a prophylactic and therapeutic factor in chronic systemic inflammation. There are a large number of studies showing a decrease of LGI by physical training. Body mass index and smoking are important factors. In Greek ATTICA study found that circulating levels of proinflammatory cytokines reduced by persons engaged in physical exercise, compared with sedentary, including healthy young people. Elucidation of the mechanism of participation muscle tissue in reducing LGI encountered a paradox significant secretion of IL-6 working muscles. There is speculation that this phenomenon is associated with the need to recharge glucose glycogen and free fatty acids working muscles. In contrast, a proinflammatory effect of IL-6, generated with IL-1 and TNF-a from activated macrophages at LGI, during exercise is generated IL-6 together with IL-10 and antagonist of IL-1. Increased levels of cortisol and anti-TNF-alpha factor during exercise also has anti-inflammatory effect. 30 minutes of moderate- intensity exercise is capable of inducing an anti-inflammatory activity of the muscle, and adipose tissue. Conclusions and prospects for further research. Working skeletal muscle is an endocrine organ, producing miokines providing anti-inflammatory effect that reduces the IR, and acting as a prophylactic and therapeutic fac- tor in LGI and associated diseases. These scientific data should be used to motivate increased physical activity as a means of prevention and treatment of diseases associated with chronic systemic inflammation. Research must continue investigate myokines spectrum allocated to working muscles with a view to improve the efficiency of physi- cal exercises.

chronic low grade inflammation, physical activity, interleukins, myokines

• Кайдашев И. П. Изменение образа жизни как часть комплексной терапии при метаболическом синдроме / И. П. Кай- дашев // Международный эндокринологический журнал. – 2012. – № 2. – С. 42.
• Bruunsgaard H. Physical activity and modulation of systemic low-level inflammation / H. Bruunsgaard // Journal of Leukocyte Biology. – 2005. – Vol. 78. – P. 819-835.
• Mattusch F. Reduction of the plasma concentration of C-reactive protein following nine months of endurance training / F. Mat- tusch, B. Dufaux, Heine [et al.] // Int. J. Sports Med. – 2001. – Vol. 2. – P. 21-22.
• Panagiotakos D. B. The associations between leisure-time physical activity and inflammatory and coagulation markers related to cardiovascular disease: the ATTICA Study / D. B. Panagiotakos, C. Pitsavos, Chrysohoou [et al.] // Prev. Med. – 2005. – Vol. 40. – P. 432-437.
• Pedersen B. K. Searching for the exercise factor: is IL-6 a candidate? / B. K. Pedersen, A. Steensberg, Fischer [et al.] // J. Muscle Res. Cell. Motil. – 2003. – Vol. 24. – P. 113-119.

«Bulletin of problems biology and medicine» Issue 3 part 1 (110), 2014 year, 190-192 pages, index UDK 616. 12:615. 22