Asmetov V. Y., Macidova U. M., Yagubov K. M., Ganiyev M. M.
The purpose of the study was to study the effect of calcium channel blockers on impaired coordination parameters caused by the introduction of typical and atypical antipsychotic drugs. Object and methods. The work is performed on 220 albino male rats, weighing 160-200 g. the Action of calcium channel blockers on the behavior and catalepsy was studied separately and with the use of antipsychotic. All the study drugs were injected intraperitoneally (I. p.) 30 min prior to testing in the following doses: verapamil (isoptin, Finland) is 5 mg/kg, 10 mg/kg, 15 mg/kg, 25 mg/kg, nifedipine (corinfarum, Germany) 5; 7,5; 10 mg/kg, diltiazem (rvi, USA) of 5, 10 and 20 mg/kg Cinnarizine (Bulgaria) 25 and 50 mg/kg, amlodipine (Germany) 5, 10 mg/kg, haloperidol (Germany) 3 mg/kg, ftorfenazina depot (England) 25 mg/kg, sulpiride (France) 100 mg/kg, clozapine (Hungary) is 10 mg/kg of the Studied drugs were previously used by us in the refinement anxiolytic and anticonvulsant activity. Effects of drugs on behavioral parameters were studied by conventional method of “open field”. And at the same time was studied the effect of neuroleptics, calcium channel blockers separately and the combined use of typical and atypical antipsychotic drugs and calcium channel blockers on the development of catalepsy. The animal was placed in the center of the field and visually checked the 5 dimensions of behavior (locomotor activity, exploratory activity, vertical activity, grooming, defecation) within 5 minutes. Catalepsy was tested with the help of the device, which gives the animals the pose of the lecturer within 3 minutes. Results and discussion. The results of these studies showed that the introduction of haloperidol (3 mg/kg), ftorfenazina depot (25 mg/kg), sulpiride (100 mg/kg) and clozapine (10 mg/kg) to intact rats was noted a significant change in behavioral indicators animals to the side of oppression. Calcium channel blockers verapamil at a dose of 5 mg/kg, nifedipine 5 mg/kg, diltiazem 5 mg/kg Cinnarizine at a dose of 25 mg/kg and amlodipine at a dose of 5 mg/kg by intraperitoneal injection to inhibit animals’ behavior and enhance the development of catalepsy induced by administration of typical and atypical antipsychotic drugs. Verapamil at a dose of 25 mg/kg nifedipine 10 mg/kg, diltiazem 20 mg/kg Cinnarizine at a dose of 50 mg/kg and amlodipine at a dose of 10 mg/kg by intraperitoneal injection improve behavioral activity and reduce the development of catalepsy induced by administration of typical antipsychotic haloperidol in a dose of 3 mg/kg, ftorfenazina 50 mg/kg and the atypical antipsychotic sulpiride in a dose of 100 mg/kg and clozapine at a dose of 10 mg/kg. Our data suggest that antagonists of calcium ions affect the appropriate behavioral responses due to stimulation of DA-ergic transmission. However, the difficulty of forming any behavioral response does not allow to unambiguously interpret the results as the fact that stimulation of only one neurotransmitter system. Therefore, we assume that the action of the tested drugs determined by a complex influence on many neurotransmitter systems involved in the formation of the behavioral response.
«Bulletin of problems biology and medicine» Issue 2 part 1 (128), 2016 year, 19-22 pages, index UDK 616.62-615.036.8
