Bosenko A. I., Filiptsova К. A., Gynzhu M. М., Pertaia O. V., Shavininа A. O.

PHYSIOLOGY

Scentific article

The article presents the results of studies regarding ascorbic acid antioxidant activity in pupils of basic school and its importance in providing the adaptive abilities of the children’s organism to dosed physical loads with reverse. The study involved 178 boys aged 8−16 years, who have performed cycle ergometric muscular activity with reverse. Children were divided into groups according to age and level of physical condition. Functional condition control of examined children was provided by the complex of methods, which included anthropophysiometric (body length, body weight, chest circumference, arm strength), as well as functional parameters of the cardiovascular system (systolic and diastolic blood pressure, electrocardiography, heart rate) and the central nervous system parameters (general functional state of the brain). On the basis of the data obtained, it can be determined that the antioxidant activity of ascorbic acid has presented the age-related dependence in ontogeny, which manifested itself in its decrease with the age increase of the pupils (inverse proportion). Performance of dosed physical loads with reverse caused significant decrease in ascorbic acid antioxidant activity in all age groups, regardless of the level of childrens’ physical condition. In groups of children with low physical activity and young athletes, the low levels of ascorbic acid antioxidant activity were detected at all stages, compared to the groups of children with high physical activity and children, who did not engage sport activities, and its recovery was less active due to systemic organism response of children and adolescents, which manifested itself in the functional activity of the brain, cardiovascular and respiratory systems, and deeper mobilization of adaptive reserves. Muscular performance in children with low physical activity and children involved in sports has resulted in deeper state of stress mobilization mechanisms of body reserves. The results of the study have determined, that body age increase and systematic training loads in response to intensive physical exertion resulted in severe vitamin deficiency of ascorbic acid caused by its active expenditure. Deficiency of ascorbic acid in the body leads to the decrease in antioxidant activity, which proves its importance as direct antioxidant agent in adaptation processes. In case of intensive muscular activity, the accumulation of free radical oxidation products in the organism occurs, which causes disorders in physiological balance between the processes of lipid peroxidation and level of antioxidant protection, and indicates the intensity of the compensatory mechanisms and adaptive capabilities of the antioxidant system to physical loads.

ascorbic acid, antioxidant system, physical loading, adaptive abilities, schoolchildren

• Adaptatsiya k stressornym situatsiyam i fizicheskim nagruzkam / F.Z. Meyerson, M.G. Pshennikova. – M.: Meditsina, 1988. – 252 s.
• Angioprotektory / O.N. Voskresenskiy, V.A. Tumanov. – K.: Zdorov’ye, 1982. – 120 s.
• Vladimirov Yu.A. Svobodnyye radikaly i antioksidanty / Yu.A. Vladimirov // Vestn. RAMN. – 1998. – T. 98, № 7. – S. 43-51.
• Dvigatel’naya aktivnost’ i zdorov’ye / N.A. Agadzhanyan, V.G. Dvoyenosov, N.V. Yermakov, G.V. Morozova, R.A. Yusupov. – Kazan’: Izd-vo KazGU, 2005. – 216 s.
• Zabolevaniya i povrezhdeniya pri zanyatiyakh sportom / A.G. Dembo. – M.: Meditsina, 1991. – 336 s.
• Kalachev I.I. Askorbinovaya kislota v oftal’mologii / I.I. Kalachev, V.P. Mozherenkov, G.L. Prokof’yeva // Vestnik oftal’mologi. – 1994. – № 1. – S. 35-36.
• Martishuk T.V. Vpliv oksidatsíynogo stresu na sistemu antioksidantnogo zakhistu organízmu shchurív / T.V. Martishuk // Vísnik Dnípropetrovs’kogo uníversitetu. Bíologíya, meditsina. – 2016. – T. 7, № 1. – S. 8-12.
• Metelitsyna I.P. Rol’ narusheniy fiziologicheskogo ravnovesiya mezhdu protsessami perekisnogo okisleniya lipidov i aktivnost’yu antioksidantnoy sistemy v patogeneze glaznykh zabolevaniy. Korrektsiya antioksidantami / I.P. Metelitsyna // Farmakologíchniy vísnik. – 1997. – № 6. – S. 52-56.
• Petrov Yu.A. Vliyaniye fizicheskikh nagruzok na sostoyaniye nekotorykh zven’yev antioksidantnoy sistemy krovi u sportsmenov Tekst / Yu.A. Petrov, L.L. Goncharova, A.O. Kovshik, H.H. Kiseleva, H.H. Makarova, B.N. Yevstigneyev // Teoriya i praktika fizich. kul’tury. – 1991. – № 8. – S. 38-40.
• Sokolenko V.L. Vpliv pomírnikh fízichnikh navantazhen’ na pokazniki ímunnoí̈ sistemi u meshkantsív radíatsíyno zabrudnenikh teritoríy / V.L. Sokolenko, S.V. Sokolenko // Vísnik Dnípropetrovs’kogo uníversitetu. Bíologíya, meditsina. – 2016. – T. 7, 1. – S. 48-52.
• Sportivna metrologíya: teoríya í praktichní aspekti: [pídruchnik] / L.P. Sergíênko. – K.: KNT, 2010. – 776 s.
• Surkina I.D. Vliyaniye defitsita vitaminov na immunitet / I.D. Surkina, G. Mateyev // Teoriya i praktika fizich. kul’tury. – 1982. – № 6. – S. 22-25.
• Trifonov O.N. Rol’ perekisnogo okisleniya lipidov v vozniknovenii khronicheskogo fizicheskogo perenapryazheniya miokarda u sportsmenov / O.N. Trifonov // Teoriya i praktika fizich. kul’tury. – 1988. – № 4. – S. 47-49.
• Khaitov R.M. Immunitet i stress / R.M. Khaitov, V.P. Leskov // Rossiyskiy fiziol. zhurnal. – 2001. – T. 87, № 8. – C. 1060-1072.
• Chumakova A.S. Izmeneniya svobodnoradikal’nykh protsessov v razlichnykh organakh krys raznogo vozrasta pri ostrom stresse / A.S. Chumakova, D.L. Teplyy, Yu.V. Nesterov // Biologicheskiye issledovaniya. – 2009. – № 4. – S. 34-37.
• Shapoval G.S. Mekhanizmy antioksidantnoy zashchity organizma pri deystvii aktivnykh form kisloroda / G.S. Shapoval, V.F. Gromova // Ukr. biokhim. zhurn. – 2003. – T. 75, № 2. – S. 5-13.
• Babizhaev M.A. Failure to withstand oxidative stress induced by phospholipid hydroperoxidases as a possible cause of the lens opacities in systemic diseases and ageing / M.A. Babizhaev // Biochim. Biophys. Acta. – 1996. – № 52. – Р. 87-99.
• Green K. Free radicals and aging of anterior segment tissues of the eye hypothesis / K. Green // Ophthaimic Res. – 1995. – V. 27, suppl. 1. – Р. 143-149.
• Jacques P.F. Epidemiologic avidense of a role of the antioxidant vitamins and carotinoids in cataract prevention / P.F. Jacques, Z.T. Chulack // Amer. J. Clin. Nutr. – 1991. – V. 53, suppl. 1. – Р. 352-355.
• Pedersen B.K. Exercise and the immune system: regulation, integration, and adaptation / B.K. Pedersen, L. Hoffman-Goetz // Physiol. Rev. – 2000. – V. 80, № 3. – P. 1055-1081.
• Robertson J.M. A possible role for vitamin C and E in cataract prevention / J.M. Robertson, A.P. Donner, J.R. Trevithich // Amer. J. Clin. Nutr. – 1991. – V. 51, suppl. 1. – Р. 346-351.
• Valko M. Free radicals and antioxidants in normal physiological functions and human disease / M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, J. Telser // Int. J. Biochem. Cell. Biol. – 2007. – V. 39, № 1. – Р. 44-84.

«Bulletin of problems biology and medicine» Issue 4 Part 3 (141), 2017 year, 389-394 pages, index UDK 577.164.2:612.66:37.015.3

10.29254/2077–4214–2017–4–3–141–389-394