Difficulty eruption of mandible third molars occurs quite often. Its distribution ranges from 35 to 50% among the patients aged 16 to 60 years old. Often this pathology accompanied by development of inflammatory complications – perikoronaritis, periostitis, cellulitis, osteomyelitis and requiring emergency removal of the causal tooth. Prevention and treatment of infectious and inflammatory complications and regeneration of bone tissue for faster healing of bone defects formed after the removal of third molars of the lower jaw are relevant and require further study. Perspective can be used for this purpose is a combination of different factions autoplazma’s blood PRF, i-PRF, a-PRF, which is rich in growth factors that stimulate the formation of endothelial vessels, bone, by influencing the proliferation, differentiation of osteoblasts, osteoclasts, and chondrocytes. The aim was to optimize recovery of bone defects created after the removal of third molars of the lower jaw due to additional use in treatment of various fractions autoplazma’s blood. Object and methods. A survey of 54 patients with retention of mandibular third molars included clinical (OPG, densitometry) and the laboratory of the (determination of antibodies in oral fluid, determining methods (osteocalcin and bone metabolism β-CrossLaps). The distribution of patients depending on the topographic anatomical position impacted molar was as follows: vertical position – in 6 patients (11.1%), with an inclination in the medial direction – in 29 patients (53.7%), horizontal position – in 19 patients (35.2%). The First, main group included 30 patients (55.5%), which after removal impacted mandible of third molars and prescribed a complex treatment that included bone defect filling blood clot own bunch of subsequent imposition of automembrana PRF and suturing wounds nodal seams. Then conducted a transitional administration of injection concentrate i-PRF. The second, control group comprised 24 patients (44.5%), in which surgery and subsequent treatment was carried out generally means: removal impacted mandible of third molars involved excision of vestibular compact plate alveolar bone. Filling the blood clot and suturing wounds Results and conclusions. The average density of newly formed bone after 3 months in the study group was on a scale of Haunsfild 220.0±39.2 ED, 6 months 573.0±41.5 ED, and 12 months 809.0±39.9 ED, well above the than in the control group. It is proved that the use of complex fractions of autoplazma’s blood PRF, a-PRF, i-PRF, reduced postoperative inflammatory symptoms and complications increases activity reparative processes in bone tissue. Should be use markers of bone metabolism in the dynamic observation for objective assessment of recovery in the area of bone defects, which formed after the removal of impacted mandible third molars. The analysis of altered markers of bone remodeling of patients in the control group showed that the substitution of the bone defect formed after impacted mandible third molar removal, blood clot in the first days after surgery in the recovery process of bone affected to a lesser extent than in patients basic groups in which treatment was conducted by a method developed.
bone defects, autoplazma’s blood, the mandibular third molars, bone metabolism
«Bulletin of problems biology and medicine» Issue 1 (135), 2017 year, 352-356 pages, index UDK 616.314.7-007:616.716.4-089:616.153
