Ivanova K.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Cardiovascular diseases are the main cause of disability and premature mortality worldwide, which necessitates a detailed study of the risk factors for cardiovascular disorder. Overweight and obesity are the most important factors that reduce the sensitivity of tissues to insulin. According to modern ideas, fatty tissue is a place for the synthesis of many adipocytokines, among which the fibroblast growth factor 21 (FRF21). The fibroblast growth factor 21 (FRF21) is a hormone-like cytokine recognized as a potent metabolic regulator. Previous studies have established lipid-lowering, anti-inflammatory and antioxidant properties of FRF21. Serum levels of FRF21 were also higher in obese patients and type 2 diabetes mellitus (DM2T), so FRF21 was suggested as a predictor of metabolic syndrome and DM2T. The aim of the study was to study the relationship between the serum fibroblast growth factor level 21 and insulin resistance syndrome in patients with coronary artery disease (CAD), depending on the presence and extent of obesity, as well as establishing an association with anthropometric indicators. Object and methods. 98 patients with CAD who were divided into 4 groups depending on the body mass index were examined. The control group consisted of 20 healthy people, corresponding to sex and age. The patients were examined according to a standard protocol. In addition, the level of FRF 21 and fasting serum insulin was determined by ELISA using the ELISA Kit AVISCERA BIOSCIENCE SK00145-01 (USA) and DRG® Insulin (DRG Instruments gmbh, Germany, Marburg) with the enzyme immunoassay. Results and discussion: the adherence of obesity in patients with IHD with an unfavorable factor in the formation of insulin resistance or type 2 diabetes. This assumption is the result of studies that determine the protective role of this cytokine in the development of changes in carbohydrate metabolism. Conclusions. The level of FRF21 is related to the degree of obesity, as well as the state of the carbohydrate profile.

fibroblast growth factor 21, insulin resistance, carbohydrate profile, coronary heart disease, obesity

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«Bulletin of problems biology and medicine» Issue 3 (145), 2018 year, 108-112 pages, index UDK 616.127-005.4-056.257-078:[577.175.72:577.112].088.6:577.121

10.29254/2077-4214-2018-3-1-145-108-112