Tykholaz V. O., Rutska I. А., Shkolnikov V. S.

LITERATURE REVIEWS

Scentific article

The study of the regularity of the fetus body development to its topography is very important for understanding the processes of organogenesis, mechanisms of normal organs’ formation, occurrence of anatomic variations and inherent defects. The available for the survey scientific works for the last decade testify to the deep research (based on modern methods) into embryogenesis and inner organs development in prenatal period of human ontogenesis. With the help of a complex of anatomical, general histological, neurohistological and immunohistochemical methods of research the regularities of the development spinal cord segments, peculiarities of the development of nuclei of the medulla oblongata in perinatal period of human ontogenesis have been studied. The structural organization of the cerebellum, mesencephalon (midbrain), the frontal lobe of the brain of human fetus at different times of fetal development are studied. However, there is scarce information on embryogenesis, peculiarities of histo-architectonics and establishment of the structures of the intermediate brain structures in the embryonic and fetal period. The analysis of the research into morphogenesis, histogenesis and topography of the diencephalon structures and namely of the thalamus in the prenatal period of human ontogenesis enables to draw the following conclusions. Nowadays the chronology of changes in macrometric thalamus parameters and its collateral ventral nuclei morphometric parameters is not studied. There is no research into the periods of accelerated growth of these structures in human fetuses and embryos in prenatal ontogenesis. The age-related peculiarities of the structure of the ependymal cell layer of the third cerebral sinus are not defined and the morphometric research into this layer is not made. The morphology of the radial glia in thalamus as well as its age-related changes in human embryos and fetuses in the prenatal period of the ontogenesis are not well scrutinized. The peculiarities of the form and structure of neuroblasts of collateral ventral nuclei of thalamus require consideration as well as the regularity of their changes in fetuses of different gestation periods. Little is known about the regularity of expression of immunohistochemical vimentin markers, S-100, synaptophysin, Кі-67, Bcl-2 in the thalamus structures of human embryos and fetuses of various gestation periods.

brain, diencephalon, thalamus, nuclei of the thalamus, prenatal period

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«Bulletin of problems biology and medicine» Issue 1 Part 1 (142), 2018 year, 56-62 pages, index UDK 612.82:611.814:618.213:57.017.642

10.29254/2077-4214-2018-1-1-142-56-62