Dihtiar V. A., Savenko M. V., Diedukh N. V.

MORPHOLOGY

Scentific article

In the case of actions of various extreme factors that affect the body, it plays a leading role the endocrine system. The adequacy and nature of the adaptive-compensatory changes in the body, which ensure the restoration and maintenance of the internal environment, depends on the change in the endocrine system. The adrenal glands, as an element of the hypothalamic-pituitary-adrenal system, are involved in the regulation of metabolism and in the adaptation of the body to adverse conditions, including when exposed to stress factors. Aim of the study. To study the morphology of the adrenal glands under conditions of increased abdominal pressure of various levels and durations. Object and methods of research. The experimental study was conducted on 48 non-linear white male rats (aged 2.5-3 months, live weight 250-300 g) of the population of the experimental biological clinic in two series of the experiment: acute and chronic. Under experimental conditions, we studied the effect of intraabdominal pressure of various modes (20, 30, and 40 mm Hg), and duration 15, 30 and 60 minutes on the adrenal glands. Results of the study and their discussion. A histological study of the cortical and medulla of the adrenal glands was performed under conditions of using various levels of intra-abdominal pressure. Conclusions. Changes in the adrenal glands in an acute experiment under the influence of increased intra-abdominal pressure appear at the vascular and cellular levels, which worsen in the form of damage at the stages of the recovery period. The most destructive regime is a duration of 60 minutes under all pressure reproductions, it was found that compared with the control group of animals on the 7th day, the total area of the adrenal glands was reduced by 21.5%, the cortical layer by 22.1%, the medulla by 8.6%, which indicates hypotrophy developing after increased intra-abdominal pressure.

adrenal glands, intra-abdominal hypertension, experimental study, histology.

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«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 300-304 pages, index UDK 611.45:612.339-047.42

10.29254/2077-4214-2019-4-2-154-300-304