The aim of the study. To investigate the features of vaginal microbiocenosis and bacterial load of the urogenital tract in pregnant women with drug addiction. Object and methods. 156 pregnant women were studied, including 96 women with drug addiction (main group). All patients underwent cytological, bacterioscopic, bacteriological examination and polymerase chain reaction to diagnose urogenital tract infections. Results. The microflora of the main group of the females was represented by the aerobes Esherihia coli, E. faecalis and Pseudomonas aerugenosa, which were found to be 4.5, 3.5, and 3.0 times more likely than in the comparison groups, respectively; this flora is gram-negative microorganisms. And also in bacteriological examination the following gram-negative anaerobes were identified: Bacteroides spp., Mobiluncus, Fusobacterium spp. and Gardnerella vaginalis – 3.7; 3.0; 3.0 and 4.7 times, respectively. PCR revealed 40 (41.6%) of the STI core group studied in clinically relevant titers (more than 104 CFU/ml) versus 10 (16.6%) in the comparison group. The incidence of cases of monoinfection of ureaplasmosis in the main group surveyed reaches 8.3%, which is more than 5 times higher than this pathology in the comparison group. Also, these women were significantly more likely to have mycoplasmosis (M. Hominis) at 5.2% versus 1.6%, respectively. Particular attention should be paid to existing STI associations, which are more commonly noted in patients in the main group. Therefore, combinations of infectious agents M. Hominis + U. Urealyticum are noted 3.4 times more often than in the comparison group, and M. genitalium + U. Urealyticum 4, 5 times, respectively. Conclusion. Thus, it can be argued that in pregnant women with drug addiction in almost 70% of the violation of the vaginal microflora occurs due to fungal microorganisms and gram-negative anaerobes, unlike women in the control group. Among the STIs for women in the main group, the most common are the association of M. genitalium + U. Urealyticum and M. Hominis + U. Urealyticum, as well as mono-infection with urea and mycoplasmosis.
drug addiction, microbiocinosis, gram-negative anaerobes, pregnant women
«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 284-288 pages, index UDK 618.177-06:618.145/.146-002-018-094-039
