Khanyukov O. O., Yehudina Ye. D., Sapozhnychenko L. V., Karakay V. L.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

This investigation aimed to determine the effectiveness of the drug therapy and lifestyle modification combination in improving the life quality and cardiovascular event prevention in hypertensive patients. The study included 30 patients with stage 2 essential hypertension who received the antihypertensive and lipid-lowering drugs and adhered to recommendations for lifestyle changes (quitting smoking and alcohol drinks, dosed physical exertion, minimizing stress) for 5 years. Before and after 5 years from the treatment onset, EQ-5D-5L survey was conducted, indicating a statistically significant (p˂0.05) improvement in the life quality of reducing discomfort by 40% from baseline, reducing anxiety and depression by 33%, recovery of daily activities by 29%. According to the visual analogue scale, we obtained a significant improvement in the subjective assessment of health status by 25%. The life quality index increased by 19%. According to Non-Laboratory Interheart Risk Score, there was a significant reduction in the cardiovascular complications risk (p˂0.05) by 38% (from 20.4 ± 2.08 (high risk) to 12.7 ± 1.8 (moderate risk) points). On the Cholesterol based Interheart Risk Score scale, there was a significant (p˂0.05) risk reduction by 45% (from 8.2 ± 1.88% (high risk) to 3.7 ± 0.65% (medium risk)). According to the results of our study, antihypertensive and hypolipidemic therapy in combination with the rejection of smoking, metered physical exercises and stress reduction have leaded to decreasing the risk of cardiovascular complications in the next 10 years from high and very high level to moderate level. The prediction of the development of cardiovascular disease complications using non-laboratory tests (NonLaboratory InterHeart Risk Score) provides the same accuracy of calculation as with the Laboratory Based InterHeart Risk Score, which includes laboratory data. According to the EQ-5D-5L questionnaire the participants of this study noted improvement in quality of life due to reducing discomfort and anxiety associated with this disease and resumption the daily activities. According to data of visual analogue scale for assessing the subjective health status, patients noted the significant improvement in their health condition (from 61.2 ± 4.91 to 76.6 ± 3.76 if p <0.05). Study shows that the risk of cardiovascular complications in patients with arterial hypertension is corrected not only by prescribing adequate therapy aimed at supporting the target blood pressure level, correcting the lipid profile, but also by providing recommendations for the lifestyle modification.

arterial hypertension, risk factors, cardiovascular complications, life quality

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«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 204-209 pages, index UDK 616.12-008.331.4-037-06:616-092.11

10.29254/2077-4214-2019-3-152-204-209