Bubalo N. M., Balan G. M., Zhminko P. G., Prodanchuk M. G., Kravchuk O. P., Rashkivska I. O., Usenko T. V., Bubalo V. O., Kolyanchuk Y. V., Kolesnyk S. D., Petroshenko G. I.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Metabolic syndrome and obesity are pathological statuses widespread in the world. Some pesticides are known to increase the risk of developing metabolic disorders and obesity. The aim of this study was to investigate the serum leptin content in 23 patient long-term after acute 2,4 D poisoning, depending on trophological status and to determine its diagnostic and prognostic significance. Serum leptin content, lipoproteins level and trophological status (waist circumference, body mass index) were studied in patients. The level of leptin was increased in almost all persons and especially in persons who had hepatosteatosis and obesity. In persons without hepatosteatosis moderately manifest excess body weight – BMI on average 31,1 ± 2,5, waist circumference – 87,7 cm. At the same time, in persons with hepatosteatosis, the indicators of trophological status were much higher – BMI averaged 42,75 ± 2.39 (p <0.05), waist circumference 116.9 ± 5.95 cm (p <0.05). It was revealed, that persons who suffered acute 2,4-D poisoning with the development of hepatosteatosis and obesity in the remote period, leptin content was almost 2.5 times higher than in the comparison group (p <0.05) and patients after 2,4-D poisoning without liver damage and without signs of hepatosteatosis (p <0.05). Determining the strength of the relationship between leptin content elevation in persons undergoing acute 2,4-D herbicide poisoning with hepatosteatosis and obesity in the remote period and anthropometric parameters and dyslipoproteinemia has a direct positive correlation (r = 0.72 and 0.64; 0.62 and 0.76, respectively). This study has shown that the assessment of leptin levels can be used as biomarker of metabolic disorders, caused by the influence of obesogenic-pesticides.

leptin, obesity, metabolic syndrome, pesticides, poisoning

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«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 84-88 pages, index UDK 612.018:616-008.9:613.25:615.9.

10.29254/2077-4214-2019-3-152-84-88