In the course of treatment with the use of dental products, in the clinical practice of the dentist, migration from structural elements and materials of various compounds, which in certain concentrations may have a negative effect on the tissues and organs of a person, is possible. In this regard, to ensure the safety of the use of materials and products in dentistry, there is a need for toxicological studies. In a toxicological experiment, the effects of samples of new material on the body of experimental animals are studied. New domestic stomatological material for making bases of demountable dentures “Stomalit” has a complex chemical composition. Its production uses a variety of chemical compounds. Therefore, the purpose of our study is to determine the toxic effect of domestic constructive material for the manufacture of the basis of dentures, on metabolic processes and biological indices of experimental animals. The object and methods of research. Experiments were carried out on rats with a weight of 190-220 g; the age of animals at the start of the experiment was 3-3.5 months. Rats were obtained from the vivarium of the central research laboratory of the Kharkiv National Pharmaceutical University. Experimental animals were divided into 2 levels of group – I (main) and II (control). The first group received an extract from the base plasma under study for three weeks daily (maximum dose 4.5-5 ml per animal weight). The control group received distilled water according to the same scheme. The evaluation of the toxic effect of the test sample in the experiment with repeated injections was carried out on the basis of changes in the indicators that characterize the peripheral blood, the functional state of the liver and kidneys, and the mass coefficient of internal organs. The state of general-trophic processes in the body of animals was estimated by the dynamics of body weight. During the whole period of the experiment, daily observation of behavior (activity, locomotor, emotional reactions), appearance (wounds, tumors, bleeding, scrotum hyperemia, etc.), food and water consumption, the state of wool, eyes, ears, limbs , teeth), physiological functions of animals (respiration, salivation, urination, defecation), survival and development of possible symptoms of toxic effects of the animal being studied. The body weight of the rats was determined weekly for 21 days. The leukocyte formula was determined: segmental neutrophils and rodenuclear neutrophils, eosinophils, lymphocytes, monocytes, basophils (microscope Micros 400, Austria). Conclusion. Thus, as a result of the study, it is safe to assert that the basic material “Stomalite” is characterized by a rather high chemical inertness, and, in general, long-term administration of “Stomalite” does not exert a toxic effect on organs and systems of experimental animals, does not cause general metabolic and biological processes.
toxicity, constructional material, prosthetic base, removable prostheses
«Bulletin of problems biology and medicine» Issue 1 Part 1 (148), 2019 year, 328-332 pages, index UDK 616.314-77-092.9-099:678.84
