The contractile activity of the human colon ensures the optimal implementation of the intestinal reservoir function, mixing of the chyme, its movement towards the rectum, etc. Accordingly, disorders of the motor function of the colon are the leading pathophysiological manifestations of many diseases and disorders of the gastrointestinal tract, such as constipation, irritable bowel syndrome, diverticulosis, tumors, etc. Motor dysfunctions of the large intestine can be the result of disturbances in the coordinated activity of the nervous system, humoral mechanisms of regulation of the motility of the gastrointestinal tract, deterioration of blood circulation in the submucosa and muscular membrane of the intestine, dystrophy of the neurons of the intermuscular neuronal plexus and other negative processes. Accordingly, a very important problem of modern physiology, gastroenterology and other areas of medicine is the possibility of potential correction of the tone and contractile activity of colon smoothmuscle cells using biologically active substances, pH changes, and the like. Perfusion of an isolated muscle strip of the sigmoid colon with saline with the addition of biologically active substances (KN4C1, calcium channel blocker foridon, potassium channel activator flocalin) modulates the frequency and amplitude of the phase components of spontaneous motor activity of smooth muscles with varying severity, and in its absence causes significant changes in muscle tone. An important role in the dynamics of the motor activity of the smooth muscle elements of the sigmoid colon is played by the level of extracellular and intracellular pH, as well as the functioning of the calcium and potassium channels of the cell membranes of smooth muscle cells, since after their blockade with the corresponding drugs, the contractile activity of the smooth muscles of the intestine significantly changes.
smooth muscles, sigmoid colon, pH, biologically active substances.
«Bulletin of problems biology and medicine» Issue 4 (158), 2020 year, 148-151 pages, index UDK 616.345+612.741+613.291
