In Azerbaijan, studies on the influence of gender, including in the normal state of carbohydrate metabolism, 6 in diabetes and pre-diabetes have not been conducted before. Goal. Study of gender as a risk factor (protection from) vitamin B12 deficiency in Azerbaijan. Methods. A study was conducted, the criteria for inclusion in which were: age over 35 years, the availability of anamnestic data on the pharmacotherapy, the availability of data to clarify the state of carbohydrate metabolism, the availability of data on vitamin B12 and some other biochemical indicators. Vitamin B12 levels were determined using the AxSYM System analyzer (Abbott, USA) using appropriate reagents (closed system). Levels of vitamin B12 from 148 pmol/l to 221 pmol/l were regarded as borderline (or mild deficiency), and levels of 148 pmol/l or less were regarded as severe vitamin B12 deficiency. Levels of fasting glycemia weredetermined by means of the device for laboratory tests of glycemia Medi Sense Precision PCx (Abbott laboratories, USA) and appropriate test strips. On the Nyco Board II (Axis-Shield, Norway), the A1c level was determined and expressed in %. The study analyzed data from 206 subjects, from which 3 main groups were formed: the SD2 Group (n=123); the prediabetes Group (n=24); the group of people without Carbohydrate Metabolism Disorders (nuo) or, alternatively, the control group (n=59). Overall, there were 109 women and 97 men among the surveyed (n=206). Differences in gender composition between the SD2 group and the control group, the SD2 group and the pre-diabetes group, the control group and the pre-diabetes group were not statistically significant (when using the χ2 method in all cases, p > 0.05). Results. In the control group, the average values of vitamin B12 were equal to 396.5 ± 145.44 pmol/l in women and 408.2 ± 130.64 pmol/l in men. In the prediabetes group, the average values of vitamin B12 were 379.5 ± 168.17 pmol/l for women and 347.2 ± 130.28 pmol/l for men. In the SD2 group, the average values of vitamin B12 were 340.2 ± 143.71 pmol/l for women and 335.1 ± 114.65 pmol/l for men. In all cases, the differences between the groups were not statistically significant (p > 0.05). Vitamin B12 deficiency in the control group was detected in 8 (13.6%) of the surveyed, while 51 people (86.4%) did not have vitamin B12 deficiency. Vitamin B12 deficiency was present in 5 women (15.2%) and 3 men (11.5%). It was absent in 28 women (84.8%) and 23 (88.5%) men. Differences in the incidence of vitamin B12 deficiency in men and women in the control group were not statistically significant (p > 0.05). In the control group the odds ratio (Odds ratio), the ratio of the probability to find a B12 deficiency in women chance of finding such men was 1,369 at the standard error of the odds ratio (S) equal 0,783, the lower limit of the confidence interval 0,295 and the upper boundary of 6,348. The extremely high range between the lower bound of the 95% confidence interval (CI) and the upper bound of the 95% confidence interval (CI) is noteworthy. The data obtained are not statistically significant (p > 0.05). Conclusions. As a result of the study, there was no dependence of vitamin B12 deficiency on gender in the absence of nuo, as well as in SD2 and prediabetes.
vitamin B12 Deficiency, gender, nuo, SD2, prediabetes.
«Bulletin of problems biology and medicine» Issue 1 (155), 2020 year, 124-128 pages, index UDK 616.136.7
