Grytcishin L. E., Fira L. S., Lykhatskyi P. H.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

The development of malignant tumors, including the correct ones, is accompanied by oxidative stress, which manifests itself at all stages of carcinogenesis. A significant number of people with cancer die from the socalled endogenous intoxication, which occurs with this pathology. To suppress tumor growth, cytostatic agents are used, which often show a side effect and cause disorders in the body. The aim of the work was to elucidate the features of the course of oxidative stress and endogenous intoxication in rats with simulated carcinogenesis against the background of the use of cytostatics. The experiments were performed on white male rats, which were colon cancer modeled by weekly subcutaneous administration of 1,2-dimethylhydrazine at a dose of 7.2 mg/kg body weight for 30 weeks. As components of cytostatic therapy, Xeloda was used in a dose of 134 mg/kg body weight of the animal for 21 days after modeling of colon adenocarcinoma. In the serum of blood and liver, the content of TBA-active products and the oxidative modification of proteins were studied. The degree of endogenous intoxication was evaluated for the content of medium weight molecules in blood serum. Under experimental carcinogenesis, there was a progressive increase in the content of TBA-active products in the blood serum and liver, and the oxidative modification of proteins and medium-weight molecules in the blood serum, the rates of which by the end of the experiment (7 months) were the highest. The use of the chemotherapeutic drug Xeloda led to an even greater increase in oxidative stress and endogenous intoxication in the affected body, which indicates a side effect when used. This leads to the search for drugs that would eliminate the negative impact of cytostatic.

oxidative stress, endogenous intoxication, carcinogenesis, cytostatic therapy.

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«Bulletin of problems biology and medicine» Issue 1 (155), 2020 year, 112-116 pages, index UDK 612.186:599.32+615.9-085]- 092.4

10.29254/2077-4214-2020-1-155-112-116