Abstract. Etiopathogenetic multifactoriality of hypeproliferative diseases of the genitals, resistance to therapy, especially in combined benign diseases of the uterus and comorbid conditions of extragenital pathology is an topical interdisciplinary problem. The treatment of gynecological patients with chronic pelvic pain syndrome, it is not always possible to achieve a stable therapeutic effect. The aim of the study: to develop, pathogenetically substantiate treatment and rehabilitation measures, takingin to account pathogenetic prerequisites, in women with proliferative diseases of the genitals.Materials and Methods. 120 women with benign hormone-dependent diseases of the genitals and chronic pelvic pain (CPP) were examined. The patients were divided into 3 clinical groups, depending on the presence and intensity of pelvic pain. The choice of treatment tactics was determined on the basis of: estrogen receptors (ER), progesterone (PGR), proliferation index (Ki-67), vasculoendothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) in the eutopic endometrium (EE), psychoemotional characteristics and intensity of pelvic pain. The dynamics of the pain level by VAS in the examined women with CPP, depending on the chosen therapeutic tactic, helped to eliminate the pain syndrome already during the first month of therapy. In the examined women, a significant (p<0.05) shift towards a weak pain level, both in the short-term and long-term prospects was revealed. Three months after the treatment, none of the women experienced severe pain by VAS, however, 77.65% indicated a moderate level of pain syndrome. This index is gradually decreasing and after a year it made up only 16.47%, the remaining 83.53% fall on a low level of pain (p<0.05). This confirms the effectiveness of the chosen treatment approach. The proposed therapeutic tactics contributed to the regress of pain syndrome in 1, 3 and 6 months, by VAS by 34.61%; 62.84% and 100% respectively. The improvement of the psycho-emotional and general condition, normalization of sleep was noted in 88.3% of women. Reducing reactive anxiety and depressive disorders was determined in 84.7% of patients, testifying to the clinical efficacy of the proposed treatment and maybe recommended for implementation in clinical practice.
benign hormone-dependent diseases of the genitals, chronic pelvic pain, markers of morphogenesis, treatment
«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 91-96 pages, index UDK 618.14 – 002.092 – 006.03:618 – 071.4 – 008.6:612.017:159.92
