Ishchenko O. V., Efimenko A. О., Andriiashyna O., Koshova I. P., Stepanskyi D. O.

LITERATURE REVIEWS

Scentific article

Abstract. Introduction. Competition between ubiquitous Pseudomonas aeruginosa and Aspergillus fumigatus is common in various ecological niches. Patients with cystic fibrosis are characterized by high microbial colonization of the airways, which determines the prognosis for their health. The purpose of the work was to describe the relationship between P. aeruginosa and A. fumigatus in people with cystic fibrosis. Materials and methods. Review of data in the scientific databases PubMed/MEDLINE, Scopus, Google Scholar on the search words «Pseudomonas aeruginosa» and «Aspergillus» and «Cystic Fibrosis». Results and their discussion. There is a competition between P. aeruginosa and A. fumigatus for nutrients in the microenvironment of the respiratory tract. Depending on the availability of growth factors, P. aeruginosa produces a range of factors, including acyl-homoserine lactones, alkyl-quinolones, rhamnolipids, phenazines, siderophores, which affect A. fumigatus. Some of these molecules are quorum-sensing signals and are used by P. aeruginosa for intercellular communication of bacterial clones. In addition, biofilm formation in A. fumigatus can be inhibited by acylhomoserine lactones and alkyl-quinolones. 3-oxo-C12-homoserine-lactone, signal quinolone Pseudomonas and its precursor 2-heptyl-4-quinolone could affect A.fumigatus biofilms and the structure of hyphae. Bacterial phenazines are differentiated to modulate the ability to produce biofilms in A. fumigatus: low reactive concentrations of reactive oxygen species serve as a signal for sporulation, but high levels exhibit toxic properties. Consequently, reproductionin A. fumigates switches from vegetative to conidia according to thegradient of phenazinesunder cultivation in mixedculture, and in general, correlate with levels of phenazines radicals in phenazines-producing redox processes. Conclusions. The interaction between P. aeruginosa and A. fumigatus plays an important role in the pathogenesis of cystic fibrosis. A better understanding of the strategies of such interactions will certainly have an impact on improving the therapeutic opportunitiesin cystic fibrosis and, consequently, the prognosis for the life and health of such patients.

Pseudomonas quinolone, Aspergillus fumigatus, biofilms.

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«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 29-34 pages, index UDK 579.262-616.24-008.8.078

10.29254/2077-4214-2021-2-160-29-34