Grigorenko A. S., Yeroshenko G. A., Shevchenko K. V., Donets I. M., Vatsenko A. V., Ulanovskaya – Tsyba N. A.

LITERATURE REVIEWS

Scentific article

Abstract. The article presents current data from domestic and foreign literature on the effect of food additive E-621 glutamate (glutamate) sodium on the digestive system. Every year humanity consumes more than 200 thousand tons of glutamate. The most famous and widespread flavor enhancer – E-621 glutamate (glutamate) sodium, the sodium salt of glutamic acid stimulates and enhances taste sensations by increasing the sensitivity of the taste buds of the tongue. After ingestion of food or drink containing monosodium glutamate, it has a narcotic effect on the body, does not contain nutrients, it is not a preservative – it is a toxin that excites the nervous system, a chemical that overstimulates brain cells, sometimes to complete control, it deceives the brain. The growing use of monosodium glutamate, a wellknown food additive (including for infants) and a component of some vaccines, is a concern due to potential human health effects, with some authors reporting adverse reactions to food additives. in children, as well as the effect of food additives, artificial sweeteners and household hygiene products on the human intestinal microbiome and its ability to ferment fibers. It has been found that the systemic availability of orally administered glutamate is very low, even after high doses. This is due to the intense metabolism in the gut, where glutamate is used as a substrate for energy production by enterocytes of the small intestine, thus limiting its absorption into the blood. Prolonged administration of 3% sodium glutamate solution to rats at a dose of 30 mg/kg body weight for 4 weeks leads to an increase in serum total and tyrosine-containing peptides, low and medium molecular weight substances, as well as an increase in the values of intoxication, which indirectly indicates to disrupt the detoxification of endogenous metabolites in the liver of animals. There are other studies, with opposite conclusions, which indicate that this substance does not pose a health hazard when used as a dietary supplement. The U.S. Food and Drug Administration have classified monosodium glutamate as a generally accepted safe substance. However, there is no consensus on a safe dose of a common dietary supplement – monosodium glutamate, the question of the mechanism of its pathogenic effect and the damaging effect of monosodium glutamate remains insufficiently studied.

sodium glutamate, food additive, digestive system, intestine, stomach.

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«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 254-257 pages, index UDK 616.3:615.24

10.29254/2077-4214-2021-1-159-254-257