SYNDROMIC COMBINED LESIONS OF ORAL STRUCTURES, SKIN, AND OTHER HUMAN ORGANS AND SYSTEMS

  2. 2026
  3. SYNDROMIC COMBINED LESIONS OF ORAL STRUCTURES, SKIN, AND OTHER HUMAN ORGANS AND SYSTEMS

Skrypnikova T. P., Zubkova L. P., Pyndus T. O., Bocharov V. A., Khmil T. A.

SYNDROMIC COMBINED LESIONS OF ORAL STRUCTURES, SKIN, AND OTHER HUMAN ORGANS AND SYSTEMS

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About the author:

Skrypnikova T. P., Zubkova L. P., Pyndus T. O., Bocharov V. A., Khmil T. A.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

There is a broad spectrum of syndromes that combine dental, oral, craniofacial, cutaneous, and systemic lesions. The aim of the study was to analyze scientific literature and systematize clinical and pathophysiological changes in syndromes involving combined damage to oral structures, skin, and other body organs and systems. An analysis of publications indexed in PubMed, Web of Science, and Google Scholar databases over the last ten years was conducted. The subject of the study was syndromic damage to oral structures in combination with cutaneous manifestations and involvement of other human organs and systems. The analysis revealed that among syndromic lesions of oral structures, several cases are classified as developmental defects. Pathological changes are most frequently observed in the lips, tongue, and salivary glands. Certain syndromes (toxico-allergic) are extremely dangerous and can be fatal. In most cases, the exact etiopathogenesis of syndromic lesions remains elusive. A significant percentage is attributed to developmental anomalies. In specific syndromes, the roles of viral, endocrine, and/or neurotrophic factors are clearly established; toxico-allergic factors are particularly hazardous, causing damage to the oral mucosa, skin, and other organs. In this regard, dentists, dermatologists, and specialists in other fields must adhere to a differentiated approach in diagnosing such diseases and providing patient care. This study promotes interdisciplinary interaction and mutual understanding among all specialists involved in the diagnostic and therapeutic management of patients with these syndromic conditions to ensure optimal personalized care within a comprehensive approach. Prospects for further research include elucidating the pathophysiological mechanisms underlying the development of syndromes with combined damage to both integumentary tissues (oral structures and skin) and reactions from other human organs and systems.

Tags:

dental syndromes, oral manifestations, skin lesions

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 2, 181, 121-126 pages, index UDC 616.314.17+616.5(083)

DOI:

10.29254/2077-4214-2026-2-181-121-126

2026 Issue 2, 181
dental syndromes oral manifestations skin lesions
27.05.2026
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