Bozhyk S. S.

DENTISTRY

Scentific article

Red lichen planus is a chronic inflammatory disease of the skin and mucous membranes; it rarely affects nails and hair; its typical elements are lichenoid papules. In the general structure of dermatological morbidity, it is from 0.16-1.2% and up to 35-70% among diseases of the oral musoca. In recent years, the number of patients with red lichen planus has increased significantly; forms that are rare and difficult to diagnose began to be registered. For dentists, the issue of early screening of the mucous membrane in patients with isolated forms of red lichen planus on the mucous membrane remains relevant. This provision became the initiator for an in-depth study of the most common clinical and morphological forms in dental practice and offering cytological guidelines, since the main difficulties are associated with the lack of a specific cytological picture of this disease. The purpose of research is to develop screening algorithms and cytospecific predictors of transformation of various clinical and morphological forms of red lichen planus under the conditions of the primary lesion localization only on the oral mucosa. The patients underwent a general clinical dental examination, and material for cytological examination was taken from the elements of the lesion, depending on the clinical and morphological form. Later, the material was subjected to the processing according to the stages of manufacturing a cytological preparation. According to the results of the research, it can be stated that the restructuring and reorganization of the cytological picture of this nosological unit are determined by the pathomorphosis of changes in the epithelial component, provided by a cascade of reactive changes in the lamina of the mucous membrane. The obtained scientific data make it possible to conduct timely cytological screening for malignancy in the early stages of the disease as well as determine the treatment scheme and predict the transformation of one clinical and morphological form into another.

red lichen planus,cellular composition,hyperkeratosis,parakeratosis,keratinization.

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«Bulletin of problems biology and medicine» Issue 3 (166), 2022 year, 519-523 pages, index UDK 616.311-091.8:616.516

10.29254/2077-4214-2022-3-166-519-523