Sohuyko R. R., Masna Z. Z., Rudnytska Kh. I., Dachno L. O., Chelpanova I. V., Fik V. B.

MORPHOLOGY

Scentific article

According to the data of modern medical literature, bone tissue is negatively affected by various factors, both external and internal. Trauma, concomitant diseases accompanied by mineral metabolism disorders, chronic intoxications, long-term and uncontrolled use of medications, especially narcotic analgesics, can lead to disturbances in the mineral composition of bone tissue and affect its ability to regenerate. The aim of our study was to establish the dynamics of the mineral composition of the bone tissue of the lower jaw after inflicting a bonedestructive trauma to animals without background pathology, on the background of long-term use of nalbuphine and after treatment with lincomycin. Object and research methods. Research material: 25 sexually mature male rats, weighing 180-200 g, at the age of 3.5 months. Modeling of the injury was carried out by breaking the integrity of the bone tissue of the lower jaw in the area of molars with the help of a drill. Opioid dependence was modeled by daily administration of the narcotic analgesic Nalbuphine. The method of atomic absorption spectral analysis (AACA) was used to determine the mineral composition. The results. The mineral composition of bone tissue at different stages of the experiment had pronounced dynamics in different groups of animals, characteristic to each of the studied elements. Conclusions. After the application of a bone-destructive trauma, the mineral composition of bone tissue during three weeks has pronounced dynamics, different for each of the eight studied mineral elements. The dynamics of the studied mineral elements during the three weeks of post-traumatic period in animals without background pathology, on the background of long-term use of Nalbuphine and in animals treated with lincomycin, is different.

bone tissue,nalbuphine,mineral composition,bone-destructive trauma.

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«Bulletin of problems biology and medicine» Issue 3 (166), 2022 year, 450-456 pages, index UDK 611.716.4-001-018.4: 612.015.31: 615.212.7: 615.33] -08

10.29254/2077-4214-2022-3-166-450-456