Cheliy A. O.

CURRENT PERSPECTIVES ON OSSEOINTEGRATION IN XENOPLASTIC AUGMENTATION OF THE ALVEOLAR PROCESS (LITERATURE REVIEW)

---

Show/Download

About the author:

Cheliy A. O.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

This study summarizes current scientific data on the osseointegration of xenogeneic bone materials in the recon struction of the alveolar process of the jaws. It has been established that bone tissue atrophy caused by tooth loss, traumatic injuries, and inflammatory processes is a common clinical problem that limits the possibility of dental implantation and necessitates the use of bone grafting materials. A bibliographic analysis of publications from the last ten years in international scientometric databases was conducted. Of 85 sources, 31 studies focused on the clin ical application of xenogeneic materials were included in the systematic analysis. It has been shown that their use provides high efficacy in the replacement of alveolar process defects, particularly in preparation for dental implanta tion, where positive clinical outcomes range from 92% to 100%. The main complications remain infection and graft rejection, with an average incidence of approximately 7.5-8.5%. Modern bone grafting techniques were analyzed, including sinus lifting, the use of bone blocks, and alveolar ridge splitting. It was established that the effectiveness of osseointegration depends on the biological properties of the material, patient age, defect localization, and ad herence to surgical protocols. Promising directions for improving the effectiveness of xenogeneic materials include their biological and physicochemical modification, impregnation with growth factors, as well as the application of tissue engineering and cellular technologies. Despite the significant clinical potential of xenogeneic materials, fur ther development of their use requires well-designed evidence-based clinical studies aimed at refining indications, optimizing application techniques, and improving treatment safety.

Tags:

Bibliography:

1. Buser D, Schenk RK, Steinemann S. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Tissue Eng. 2020;8(64):383-99. DOI: 10.1002/jbm. 820250708.
2. Charalambides C, Beer M, Cobb AG. Poor results after augmenting autograft with xenograft (Surgibone) in hip revision surgery. Acta Orthop. 2015;3(98):34-40. DOI: 10.1080/17453670510041547.
3. Levai JP, Bringer O, Descamps S, Boisgard S. Xenograftrelated complications after filling valgus open wedge tibial osteotomy defects. Rev Chir Orthop Reparatrice Appar Mot. 2018;89(8):707-711.
4. Kubosch EJ, Bernstein A, Wolf L, Fretwurst T. Clinical trial and in-vitro study comparing the efficacy of treating bony lesions with allografts. J Oral Maxillofac Surg. 2017;55(8):822-829. DOI: 10.1186/s12891-016-0930-1.
5. Al Qabbani A, Al Kawas S, A Razak NH, Al Bayatti SW. Threedimensional radiological assessment of alveolar bone volume preservation using bovine bone xenograft. J Craniofac Surg. 2018;29(2):e203-e209. DOI: 10.1097/SCS. 0000000000004263.
6. Anastasieva EA, Sadova MA, Voropaeva AA, Kirilova IA. The use of autografts and allografts to replace bone defects during resection of bone tumors. Traumatology and orthopedics. 2017;23(3):148-155. DOI: 10.21823/ 2311-2905-2017-23-3-148-155.
7. Antunes AA, Grossi-Oliveira GA, Martins-Neto EC, Almeida AL. Treatment of circumferential defects with osseoconductive xenografts of different porosities: a histological, histometric, resonance frequency analysis, and micro-CT study in dogs. Clin Implant Dent Relat Res. 2015;17(1):e202-20. DOI: 10.1111/cid.12181.
8. Athanasiou VT, Papachristou DJ, Panagopoulos A, Saridis A. Histological comparison of autograft, allograft-DBM, xenograft, and synthetic grafts in a trabecular bone defect: an experimental study in rabbits. Med Sci Monit. 2010;16(1):24.
9. Benlidayi ME, Tatli U, Kurkcu M, Uzel A, Oztunc H. Comparison of bovine derived hydroxyapatite and autogenous bone for secondary alveolar bone grafting in patients with alveolar clefts. J Oral Maxillofac Surg. 2012;70(1):e95-e102. DOI: 10.1016/j.joms.2011.08.041.
10. Bessa PC, Casal M, Reis RL. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue EngRegen Med. 2022;2(2-3):81-96. DOI: 10.1002/term.74.
11. Boden SD. Biology of lumbar spine fusion and the use of bone graft substitutes: present, future, and next generation for latitudinal plastic surgery. Biomed Mater Res. 2021;25(7):889-902. DOI: 10.1089/107632700418092.
12. Bigham-Sadegh A, Oryan A. Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures. Int Wound J. 2015;12(3):238-247. DOI: 10.1111/iwj.12231.
13. Bovkis GYu, Kulyaba TA, Kornilov NN. Compensation of defects of the metaepiphyses of the femur and tibia in revision knee arthroplasty - methods and results of their application (literature review). Traumatology and orthopedics. 2016;22(2):101-113. DOI: 10.21823/2311 2905-2016-0-2-101-113.
14. Boyko EM, Brusnitsin DA, Dolgalev AA, Zelensky VA. Minimally invasive method of guided bone regeneration of alveolar ridge. Medical Alphabet. 2017;298(1):5-9. DOI: 10.14300/mnnc.2021.16040.
15. Brett E, Tevlin R, McArdle A, Seo EY, Chan CKF, Wan DC. Human adipose-derived stromal cell isolation methods and use in osteogenic and adipogenic in vivo applications. Curr Protoc Stem Cell Biol. 2017;43:2H.1.1-2H.1.15. DOI: 10.1002/cpsc.41.
16. Bukharova TB, Volkov AV, Voronin AS, Filimonov KA. Development of a tissue-engineered construct based on multipotent human adipose tissue stromal cells transfected with the bone morphogenic protein BMP-2 gene for sinus lifting. Biomed Mater Res. 2013;12(3):122-126. DOI: 10.1007/s10517-013-2294-y.
17. Calori GM, Mazza E, Colombo M, Ripamonti C. The use of bone-graft substitutes in large bone defects: any specific needs? Injury. 2011;42(2):S56-63. DOI: 10.1016/j.injury.2011.06.011.
18. De Bruyckere T, Eghbali A, Younes F, Cleymaet R. A 5-year prospective study on regenerative periodontal therapy of infrabony defects using minimally invasive surgery and a collagen-enriched bovine-derived xenograft. Clin Oral Investig. 2018;22(3):1235-1242. DOI: 10.1007/s00784-017-2208-x.
19. Chen M, Xu Y, Zhang T, Ma Y, Liu J, Yuan B. Mesenchymal stem cell sheets: a new cell-based strategy for bone repair and regeneration. Biotechnol Lett. 2019;41(3):305-318. DOI: 10.1007/s10529-019-02649-7.
20. Aghazadeh A., Rutger Persson G., Renvert S. A singlecentre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months. J Clin Periodontol. 2012;39(7):666-673. DOI: 10.1111/j.1600 051x.2012.01880.x.
21. Cho JS, Yoo DS, Chung YC, Rhee SH. Enhanced bioactivity and osteoconductivity of hydroxyapatite through chloride substitution. J Biomed Mater Res A. 2014;102(2):455-469. DOI: 10.1002/jbm.a.34722.
22. Dimitriou R, Jones E, McGonagle D, Giannoudis PV. Bone regeneration: current concepts and future directions. BMC Med. 2011;9:66. DOI: 10.1186/1741-7015-9-66.
23. Diesel CV, Ribeiro TA, Guimarães MR, Macedo CAS, Galia CR. Acetabular revision in total hip arthroplasty with tantalum augmentation and lyophilized bovine. Clin Oral Investig. 2017;22(8):1773-1779. DOI: 10.1016/j.rboe. 2017.08.009.
24. Jambhekar S, Kernen F, Bidra AS. Clinical and histologic outcomes of socket grafting after flapless tooth extraction: a systematic review of randomized controlled clinical trials. J Prosthet Dent. 2015;113(5):371-382. DOI: 10.1016/j.prosdent.2014.12.009.
25. Elliot RR, Richards RH. Failed operative treatment in two cases of pseudarthrosis of the clavicle using internal fixation and bovine cancellous xenograft (Tutobone). J Pediatr Orthop B. 2011;20(5):349-353. DOI: 10.1097/BPB.0b013e328346c010.
26. Galia CR, Lourenço AL, Rosito R, Souza Macedo CA, Camargo LM. Physicochemical characterization of lyophilized bovine bone grafts. Rev Bras Ortop. 2015;46(4):444-451. DOI: 10.1016/S2255-4971(15)30260-3.
27. García JR, García AJ. Biomaterial-mediated strategies targeting vascularization for bone repair. Drug Deliv Transl Res. 2016;6(2):77-95. DOI: 10.1007/s13346-015-0236-0.
28. Go A, Kim SE, Shim KM, Lee SM, Choi SH. Osteogenic effect of low temperatureheated porcine bone particles with рlatelet-rich рlasma in a rat calvarial defect model. J Biomed Mater Res A. 2014;102(10):3609-3617. DOI: 10.1002/jbm.a.35022.
29. Gothard D, Smith EL. Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man. Eur Cell Mater. 2024;6(28):166-208. DOI: 10.22203/ecm.v028a13.
30. Ibrahim MS, Raja S, Haddad FS. Acetabular impaction bone grafting in total hip replacement. Bone Joint J. 2013;95-B(11(A)):98-102. DOI: 10.1302/0301-620X.95B11.32834.
31. Einhorn TA. Enhancement of fracture-healing. Improving fracture healing with deproteinized and delipidized xenografts J Bone Joint Surg Am. 2025;77:940-956. DOI: 10.2106/00004623-199506000-00016.

Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 1, 180, 143-151 pages, index UDC 616.71-089.844:616.314.17

DOI:

10.29254/2077-4214-2026-1-180-143-151