Dovgan R. R., Masna Z. Z.
ANALYSIS OF THE DYNAMICS OF FEMORAL BONE TISSUE DENSITY UNDER EXPERIMENTAL HYPODYNAMIA
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About the author:
Dovgan R. R., Masna Z. Z.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
Hypodynamia, caused by reduced physical load and a general decrease in physical activity in modern humans, has a negative impact on the body overall and on bone tissue in particular. A study conducted on 20 white outbred sexually mature male rats aged 3-3.5 months and weighing 180-200 g, subjected to experimentally induced hypodynamia, allowed us to determine its effect on the condition of bone tissue in different regions of the rat femur. Forced hypodynamia was modeled by immobilizing the lumbosacral region and hind limbs using a plaster cast of the coxite type, entirely restricting movement in the hip and knee joints. The density of femoral bone tissue in the areas of the head, neck, greater trochanter, and proximal diaphysis was assessed using radiovisiographic examination. The unit of tissue density measurement was the conditional gray level unit (CGLU). It was established that the highest density values were observed in the greater trochanter, slightly lower in the femoral head and proximal diaphysis, and the lowest in the femoral neck. After six weeks of immobilization, bone density decreased compared to normal values by 8% in the femoral head, 5% in the neck, 7% in the greater trochanter, and 2% in the proximal diaphysis. Two weeks after cast removal, density remained below normal by 1% in the head region, 3% in the neck, 6% in the greater trochanter, and 1% in the proximal diaphysis. The obtained data correspond with the results of other authors and significantly expand our understanding of the effects of hypodynamia on bone tissue.
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Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 312-317 pages, index UDC 611.718.4-018.4:612.015.31:612.76-08
