Hrytsuliak B. V., Hrytsuliak V. B., Hlodan O. Y., Ivasiuk I. Y., Mykytyn T. V., Sluchyk I. Y.

MORPHOLOGY

Scentific article

The characteristics of hemodynamics and structural and functional changes in the testicles and ejaculate of infertile men of mature age with bronchial asthma were studied. The methods of ultrasound scanning, color ultrasound angiography, histology, morphometry, laboratory diagnosis of ejaculate and statistics were used. Using the method of ultrasound scanning and color ultrasound angiography of the testicles, the volume of the testicles and such hemodynamic parameters as peak arterial blood flow, diastolic blood flow, average blood flow and volumetric blood flow were determined in 15 infertile men. In the urological department of the communal noncommercial enterprise «Regional Clinical Hospital of the Ivano-Frankivsk Regional Council» the histostructure of the testicles was examined in 7 testicular biopsies with this pathology, and the concentration of spermatozoa, their morphological form and motility in the ejaculate according to the generally accepted method. The concentration of testosterone in the blood was studied by enzyme immunoassay using an analytical analyzer IMMULITE–2000 (Siemens Healthcare Diagnostics Inc., США). It was found that under these conditions, the volume of the testicles decreases to (15.30±1.45) cm3 against (19.60±0.70) cm3 . The maximum blood flow velocity in the testicular artery within the spermatic cord decreases to (13.9±0.7) cm/s against (19.0±1.5) cm/s in men of the control group, and the average minimum blood flow velocity is to (5.7±0.2) cm/s, versus (8.2±1.0) cm/s, respectively. The volumetric blood flow in the testicular artery decreases to (8.3±0.7) ml/s against (16.5±1.2) ml/s in the control. The average linear velocity of blood flow in the testicular veins decreases to (6.9±0.4) cm/s, and the volumetric blood flow velocity in them to (5.9±0.1) ml/min against (8.0± 0.2) cm/s in control. In testicular biopsies with this pathology, the diameter of convoluted seminiferous tubules decreases to (160.8±5.3) μm, against (190.6±5.4) μm in the control. 1–2 layers of spermatogonia and spermatocytes are adjacent to the thickened own shell of convoluted seminiferous tubules. The concentration of spermatozoa in the ejaculate of men decreases to (25.30±4.60) million/ml, against (73.5±3.60) million/ml. The number of spermatozoa with pathology of the head increases to (20.18±3.50)%, against (11.78±0.36)% in the control, and the number of spermatozoa with pathology of the main part of the flagellum to (18.60±3.50)% against (9.06±0.43)%. The level of testosterone in the blood decreases to (330.50±10.70) ng/dL, against (780.30±21.40) ng/dL in men of the control group.

testicle,hemodynamics,spermatogenesis,bronchial asthma.

1. Kachkovska VV. Kontrol bronkhialnoi astmy, asotsiiovanoi z ozhyrinniam, zalezhno vid viku debiutu ta Arg16Gly polimorfizmu hena β2- adrenoretseptora. Ukrainskyi terapevtychnyi zhurnal. 2021;3:28-34. DOI: https://doi.org/10.30978/UTJ2021-3-28. [in Ukrainian].
2. Alyavi AL, Rahimova DA, Tillaeva ShSh, Sabirzhanova ZT. Otsinka stanu ventyliatsiinoi funktsii lehen za rozvytku lehenevoi hipertenzii u khvorykh na bronkhialnu astmu u vzaiemozviazku z porushenniamy endotelii-zalezhnoi vazo dylatatsii. Ukrainskyi terapevtychnyi zhurnal. 2019;1:14-17. DOI: https://doi.org/10.30978/UTJ2019-1-14. [in Ukrainian].
3. Tarlovskaya EI, Odegova AA. Sovremennyiy vzglyad na vozmojnosti antigipertenzivnoy terapii u patsientov s sochetaniem arterialnoy gipertenzii i bronhialnoy astmyi (obzor literaturyi). Mіjnarodniy medichniy jurnal. 2018;24(1):19-24.
4. Kochuieva MM, Shkliar SP, Tymchenko HA, Kochuiev HI, Khodosh EM, Psarova VH, et al. Osoblyvosti komorbidnoho perebihu bronkhialnoi astmy ta hostroi koronavirusnoi infektsii. Mizhnarodnyi medychnyi zhurnal. 2021;2:10-15. [in Ukrainian].
5. 5rasiuk IV, Kondratiuk VE, Krasiuk AI, Fedoryshyn GV. Ultrasound diagnostics of gastroesophageal reflux in the patients with bronchial asthma. Ukrainskyi terapevtychnyi zhurnal. 2017;3:32-37. [in Ukrainian].
6. Reheda MS. Bronkhialna astma: monohrafiia. Lviv: Spolom; 2004. 104 s. [in Ukrainian].
7. Neiko YeM, Cherniuk NV, Kovalchuk LIe. Bronkhialna astma: kliniko-henetychni aspekty patoheezu, diahnostyky, likuvannia, profilaktyky. K.: Zdorovia; 2003. 166 s. [in Ukrainian].
8. Tsymbalista OL, Semianchuk VB. Bronkhialna astma ta nedyferentsiiovana dysplaziia spoluchnoi tkanyny u ditei: osoblyvosti kliniky, diahnostyky i likuvannia: monohrafiia. Ivano-Frankivsk; 2014. 80 s. [in Ukrainian].
9. Nazarenko KV. Osoblyvosti funktsii zovnishnoho dykhannia ta vidpovidi na bronkholityk khvorykh na poiednanu patolohiiu bronkhialnoi astmy ta KhOZL. Ukrainskyi terapevtychnyi zhurnal. 2017;2:78-84. [in Ukrainian].
10. Bisyuk YuA. Svyaz polimorfizma C159T gena retseptora CD14 s antiendotoksinovyim immunitetom u bolnyih s atopicheskoy i neatopicheskoy bronhialnoy astmoy. Ukraіnskiy terapevtichniy jurnal. 2015;2:44-50.
11. Hrytsuliaka BV. Zminy v orhanakh kalytky ta peredmikhurovii zalozi, zumovleni vikom i rozladamy krovoobihu: monohrafiia . IvanoFrankivsk: Prykarpat. nats. un-t im. Vasylia Stefanyka; 2019. 159 s. [in Ukrainian].
12. Hrytsuliak BV, Spaska AM, Hrytsuliak VB, Ivasiuk II, Khallo OIe. Klinichna anatomiia yaiechka: monohrafiia. Ivano-Frankivsk: Simyk; 2012. 144 s. [in Ukrainian].

«Bulletin of problems biology and medicine» Issue 3 (166), 2022 year, 364-370 pages, index UDK 611. 631:616

10.29254/2077-4214-2022-3-166-364-370