Shatorna V. F., Lomyga L. L., Zemlyanyi O. A.
EFFECTS OF ISOLATED CADMIUM CHLORIDE ADMINISTRATION ON CARDIOGENESIS IN RATS AND THE SEARCH FOR POTENTIAL MODULATORS OF CADMIUM CARDIOTOXICITY IN A CHRONIC EXPERIMENT
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About the author:
Shatorna V. F., Lomyga L. L., Zemlyanyi O. A.
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PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH
Type of article:
Scientific article
Annotation:
The aim of the experimental study was to establish the spectrum of morphometric and morphological changes in the hearts of rat embryos after chronic daily isolated and combined exposure to cadmium chloride with copper and zinc succinate. The toxic effect of cadmium on embryonic heart morphogenesis led to a slowdown in the development of myocardial tissue, which was most pronounced at the initial stages of cardiogenesis. With isolated exposure to cadmium on the 13th day of the study, a decrease in the thickness of the ventricular myocardium, a decrease in the number of formed trabecular structures and the presence of cardiogel residues in the walls of the embryonic heart were recorded. This indicates the intensity of the process of epithelial-mesenchymal transformation of cells, while in the control group the cardiogel was almost completely reduced, and the trabeculae were more numerous and denser. At the final stages of cardiogenesis, both under the influence of cadmium alone and in combination with copper succinate, histological examination revealed myocardial hypertrophy and dilation of the diameter of subepicardial vessels with significant blood filling, which is considered an indicator of the hypoxic state of the embryo. Zinc succinate has more pronounced bioantagonistic properties compared to copper succinate according to the studied parameters when using the stated dose and method of administration in experimental conditions.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 78-81 pages, index UDC 611.12–053.13:546.48’131:546.461.4:616–091.8–092.9
