Ohinska N. V., Nebesna Z. M., Kulbitska V. V.
SUBMICROSCOPIC CHANGES IN CEREBELLAR CORTEX ASTROGLIA OF WHITE RATS UNDER EXPERIMENTAL THERMAL SKIN INJURY
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About the author:
Ohinska N. V., Nebesna Z. M., Kulbitska V. V.
Heading:
PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH
Type of article:
Scientific article
Annotation:
This study presents the results of a morphological analysis of submicroscopic changes in cerebellar astrocytes of white rats at various time points following experimentally induced thermal skin injury. The aim of the work was to determine the dynamics of ultrastructural alterations in astroglia as a response of the central nervous system to a remote damaging factor. The experiment was carried out on 60 adult white rats with a reproduced burn injury, followed by examination of cerebellar tissue on days 1, 7, 14, and 21. Electron microscopic assessment revealed a sequential progression of pathological changes in glial cells: from early swelling of processes, expansion of the perinuclear space, and destruction of the rough endoplasmic reticulum on days 1-7, to profound dystrophic and degenerative alterations on days 14-21. In the later periods, deformation of nuclei, marginalization of dense heterochromatin, marked reduction of organelles, and mitochondrial ultrastructural disturbances were observed. The obtained results indicate a high sensitivity of cerebellar astrocytes to endogenous intoxication arising from thermal skin injury and demonstrate the systemic nature of the glial response to burn trauma. The study expands current understanding of the mechanisms underlying glial dysfunction and may contribute to the development of early diagnostic criteria and strategies for mitigating secondary neural tissue damage.
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Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 58-60 pages, index UDC 611.018.54:611.817.1-018.2:616-001.17-092.9(043.3)
