Myronyuk A. A., Dymar N. M.

CLINICAL AND MORPHOLOGICAL PERSPECTIVES ON THE PREVENTION OF GASTROINTESTINAL ANASTOMOTIC FAILURE: THE ROLE OF THE MICROBIOME AND MATRIX METALLOPROTEINASES

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About the author:

Myronyuk A. A., Dymar N. M.

Heading:

PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

Type of article:

Scientific article

Annotation:

In surgical practice, formation of gastrointestinal anastomoses is quite common, most frequently indicated for the treatment of tumors, a significant share is also occupied by bariatric interventions and emergency operations (for bowel obstruction, perforations, etc.). Anastomotic leak is a common postoperative complication. To understand the pathogenesis of these complications, it is necessary to study in detail all stages of tissue regeneration after surgery, taking into account the specific features of its healing under conditions of a high bacterial load and enzymatic activity of the endoluminal environment of the stomach and intestine, with the subsequent use of these data to find methods to minimize the risks of such a complication in the patient. The results of the analysis of scientific literature indicate three consecutive stages of tissue repair: inflammation, proliferation and remodeling, the course of which depends on the composition of the intestinal microbiome and nutritional support of the patient.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 55-57 pages, index UDC 616.34-089.87-036.8+579.262+577.152

DOI:

10.29254/2523-4110-2025-4-179/addition-55-57