Yuryk I. I., Yuryk Ya. I., Kuziv O. Ye.

MORPHOMETRIC FEATURES OF REMODELING OF THE ARTERIES OF THE POSTERIOR LIMBS OF PRE-REPRODUCTIVE AGE RATS UNDER CONDITIONS OF EXPERIMENTAL HYPERURICEMIA AND ITS COMBINATION WITH HYPERCHOLESTEROLEMIA

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About the author:

Yuryk I. I., Yuryk Ya. I., Kuziv O. Ye.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

In recent decades, hyperuricemia has been recognized as one of the factors contributing to the development of hypertension, ischemic heart disease, heart failure, metabolic syndrome, stroke, and subclinical atherosclerosis in young people. However, the consequences of the combined effects of hyperuricemia and hypercholesterolemia are controversial and require clarification and supplementation. The experiment involved 56 white laboratory rats and 8 intact animals. The rats were removed from the experiment after 15, 30, and 45 days. The results of the study indicate that in pre-reproductive rats with hyperuricemia remodeling of the vessel walls occurs, leading to narrowing of the lumen of all arteries, but the most significant changes concern large-caliber arteries, especially the popliteal artery, in which the internal diameter decreased by 9,26% after 45 days of the experiment, and the thickness of the media and intima increased by 14% and 9,20%, respectively. Under conditions of binary influence of hyperuricemia with hypercholesterolemia, uniform remodeling of the arteries of all sections of the limb is observed, in particular, the thickness of the media of the femoral artery increases by 16.3%, the popliteal artery – by 16.33%, and the tibial artery – by 14.51%, the intima thickness increases by 10.42%, 10.71% and 10.05% in the respective study areas, which is higher than in hyperuricemia.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 443-449 pages, index UDC 616.13-018.2-092-099:612.017:599.736-053.4

DOI:

10.29254/2077-4214-2025-3-178-443-449