Prokopiv Kh. I., Fedorov S. V.
THE ROLE OF INFLAMMATORY INDICES IN THE PROGRESSION OF ATRIAL FIBRILLATION
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About the author:
Prokopiv Kh. I., Fedorov S. V.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia and accounts for a substantial proportion of the cardiovascular disease epidemic in the 21st century. Over the past decades, along with traditional factors of arrhythmia pathogenesis, the role of inflammation in atrial myocardial remodelling and the development of electrical instability has been studied. The aim of the study was to evaluate the role of leukocyte inflammation indices in the progression of atrial fibrillation. A total of 121 patients with AF were examined and divided according to the form of the disease: paroxysmal, persistent, and permanent. Leukocyte inflammatory indices were calculated, including the lymphocyte-monocyte ratio (LMR), neutrophil-monocyte ratio (NMR), systemic immune response index (SIRI), neutrophil-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and platelet-to-lymphocyte ratio. It has been noted that the most common comorbidities in AF, regardless of its form, are arterial hypertension and chronic kidney disease. As AF progresses, a decrease in the number of leukocytes and an increase in the number of platelets in the blood are observed. An increase in inflammation indices was observed as the disease progressed. Thus, AF is characterised by the activation of chronic low-intensity inflammation. As the disease progresses and transforms into a permanent form, indicators of inflammation increase, as evidenced by a rise in the mean values of leukocyte inflammation indices.
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Bibliography:
- Linz D, Gawalko M, Betz K, Hendriks JM, Lip GYH, Vinter N, et al. Atrial fibrillation: epidemiology, screening and digital health. Lancet Reg Health Eur. 2024;37:100786. DOI: 10.1016/j.lanepe.2023.100786.
- Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020;76(25):2982-3021. DOI: 10.1016/j.jacc.2020.11.010.
- Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke. 2021;16(2):217-221. DOI: 10.1177/1747493019897870.
- Ihara K, Sasano T. Role of Inflammation in the Pathogenesis of Atrial Fibrillation. Front Physiol. 2022;13:862164. DOI: 10.3389/fphys.2022.862164.
- Nso N, Bookani KR, Metzl M, Radparvar F. Role of inflammation in atrial fibrillation: A comprehensive review of current knowledge. J Arrhythm. 2020;37(1):1-10. DOI: 10.1002/joa3.12473.
- Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, et al. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;45(36):3314-3414. DOI: 10.1093/eurheartj/ehae176.
- Wang RH, Wen WX, Jiang ZP, Du ZP, Ma ZH, Lu AL, et al. The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune- inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front Immunol. 2023;14:1115031. DOI: 10.3389/fimmu.2023.1115031.
- Antoun I, Layton GR, Nizam A, Barker J, Abdelrazik A, Eldesouky M, et al. Hypertension and Atrial Fibrillation: Bridging the Gap Between Mechanisms, Risk, and Therapy. Medicina (Kaunas). 2025;61(2):362. DOI: 10.3390/medicina61020362.
- Ding WY, Gupta D, Wong CF, Lip GYH. Pathophysiology of atrial fibrillation and chronic kidney disease. Cardiovasc Res. 2021;117(4):1046-1059. DOI: 10.1093/cvr/cvaa258.
- Rienstra M, Sun JX, Magnani JW, Sinner MF, Lubitz SA, Sullivan LM, et al. White blood cell count and risk of incident atrial fibrillation (from the Framingham Heart Study). Am J Cardiol. 2012;109(4):533-7. DOI: 10.1016/j.amjcard.2011.09.049.
- Weymann A, Ali-Hasan-Al-Saegh S, Sabashnikov A, Popov AF, Mirhosseini SJ, Nombela-Franco L, et al. Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review. Med Sci Monit Basic Res.2017;23:58-86. DOI: 10.12659/msmbr.902557.
- Bondareva OO, Fedorov SV. Markers of low-grade inflammation in patients with acute coronary syndrome and 2 type diabetes mellitus. Prykarpatskii visnyk naukovogo tovarystva imeni Shevchenka. Puls. 2022;16-17(61-62):110-118. DOI: 10.21802/2304-7437-2021-2022-16-17(61-62)-110-118.
- Bao Q, Liu T, Song H, Bao W, Fan W. Prognostic Role of Inflammatory Hematologic Indices in Predicting Acute Coronary Syndrome in Elderly Patients with Chronic Coronary Syndrome. J Inflamm Res. 2025;18:9637-9653. DOI: 10.2147/JIR.S528161.
- Poledniczek M, Kronberger C, List L, Gregshammer B, Willixhofer R, Ermolaev N, et al. Leukocyte Indices as Markers of Inflammation and Predictors of Outcome in Heart Failure with Preserved Ejection Fraction. J Clin Med. 2024;13(19):5875. DOI: 10.3390/jcm13195875.
Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 3,178, 220-225 pages, index UDC 616.1+616-002+616-092.6+616.125.2
