Ogonovskyi R. Z., Melnychuk Yu. M., Slobodian R. V.

DYNAMICS OF PRO- AND ANTI-INFLAMMATORY CYTOKINE LEVELS IN THE BLOOD PLASMA OF EXPERIMENTAL ANIMALS FOLLOWING TOPICAL APPLICATION OF HYDROGEL DRESSINGS

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About the author:

Ogonovskyi R. Z., Melnychuk Yu. M., Slobodian R. V.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Various pro- and anti-inflammatory cytokines play crucial roles in the development of acute inflammatory processes. Depending on their effect on inflammatory processes, interleukins are divided into pro-inflammatory (IL-6) and anti-inflammatory (IL-10). The aim of the study was to analyze the dynamics of pro- and anti-inflammatory cytokines in the blood plasma of rats in an experiment using hydrogel dressings saturated with silver ions and an antioxidant drug for the local treatment of inflammatory processes. The experimental study was conducted on 80 sexually mature male rats. The healing of an experimental infected wound was studied using hydrogel dressings saturated with medicinal substances. The effectiveness of local therapy was assessed using biochemical methods. Analysis of the dynamics of the pro- and anti-inflammatory balance showed that the greatest manifestation of the inflammatory process and suppression of the body's compensatory reactions was observed on the third day. Indicative data on the relative ratio of the course of the inflammatory process were obtained on the seventh day. The highest result was in the control group – 2.719±0.55 IU, which clearly reflected the general tendency towards the equalization of pro- and anti-inflammatory reactions in the animals' bodies. However, in the third experimental group, it was even lower (1.094±0.23 IU) than the normal value, which indicates the predominance of anti-inflammatory reactions of the body to damage when using hydrogel dressings saturated with silver ions and an antioxidant preparation. On the 10th day, the body's anti-inflammatory defense mechanisms intensify, with parallel processes of inflammation subsiding. The results obtained on the 14th day of the experiment did not differ statistically significantly from the norm in all animal groups. The use of hydrogel dressings reduces the duration of treatment of the inflammatory process.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 202-213 pages, index UDC 616.155.3-097.37-07:615.262.1.454.1]-092.9

DOI:

10.29254/2077-4214-2025-3-178-202-213