FEATURES OF VISUAL ACUITY IN PEOPLE WITH MYOPIA AND NOSOGENIES

Drozdov V. O., Matsuga O. M.

FEATURES OF VISUAL ACUITY IN PEOPLE WITH MYOPIA AND NOSOGENIES


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About the author:

Drozdov V. O., Matsuga O. M.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The prevalence of myopia is increasing significantly worldwide, so the aim of this study was to evaluate the characteristics of ophthalmic biometric parameters in individuals with myopia and nosogenies. 200 people with myopia were examined, among them: 25 people without nosogenies; 23 patients with dysthymia, 8 people with other persistent personality changes; 60 patients with neurasthenia. All examined were subjected to: visiometry, refractokeratometry, measurement of intraocular pressure. Regardless of the features of nosogenies, all patients have differences in the visiometric corrections of Sphere (D) and Cylinder ax°. However, there are also features: in people with dysthymia – uncorrected distance visual acuity, refractometry of Sphere (D) and Cylinder (D), ocular pressure, keratometry R2 (D); with other persistent personality changes – uncorrected distance visual acuity, visiometric correction of Cylinder (D). Factors affecting uncorrected visual acuity in all myopic individuals include: Sphere (D) refractometry in normal conditions and Cylinder (D) in cycloplegia, age, gender, ergopathic type of attitude to the disease, neuroticism, psychopathy, length of the anterior-posterior axis of the eye, keratometry of the weak meridian in (D), the smallest corneal curvature (mm), emotional stability, depression, corneal thickness at the central point, hypochondria, health, compared to the previous year. These factors should be taken into account when developing correction programs for individuals with myopia.

Tags:

correlation analysis, cycloplegia, multiple linear regression analysis, myopia, nosogenies, refractometry, visiometry, visual acuity

Bibliography:

  1. Martínez-Albert N, Bueno-Gimeno I, Gené-Sampedro A. Risk Factors for Myopia: A Review. J Clin Med. 2023;12(18):6062. DOI: 10.3390/jcm12186062.
  2.  Madsen HØ, Dam H, Hageman I. High prevalence of seasonal affective disorder among persons with severe visual impairment. Br J Psychiatry. 2016;208(1):56-61. DOI: 10.1192/bjp.bp.114.162354.
  3. Ma Y, Jiang D, Li JY, Zheng G, Deng Y, Gou1 X, et al. Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases. Transl Psychiatry. 2025;15:24. DOI: https://doi.org/10.1038/s41398-025-03243-4.
  4.  Mi Y, Chen K, Lin S, Tong L, Zhou J, Wan M. Lactobacillaceae-mediated eye-brain-gut axis regulates high myopia-related anxiety: from the perspective of predictive, preventive, and personalized medicine. EPMA Journal. 2024;15:573-585. DOI: https://doi.org/10.1007/s13167-024-00387-z.
  5.  Wong W, Qin Y, Liu C Zhang S, Jiang Y, Zeng Y, et al. The Association between Myopia and Anxiety: a bidirectional two-sample Mendelian randomization study. Ophthalmology Science. 2025;5(5):100832. DOI: https://doi.org/10.1016/j.xops.2025.100832.
  6. Tariq F, Mobeen R, Wang X, Lin X, Bao Q, Liu J, et al. Advances in myopia prevention strategies for school-aged children: a comprehensive review. Front Public Health. 2023;11:1226438. DOI: 10.3389/fpubh.2023.1226438.
  7. Zhu X, Meng J, Han C, Wu Q, Du Y, Qi J, et al. CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Discov. 2023;9(1):94. DOI: 10.1038/s41421-023-00588-2.
  8. Yokoi T, Moriyama M, Hayashi K, Shimada N, Tomita M, Yamamoto N, et al. Predictive factors for comorbid psychiatric disorders and their impact on vision-related quality of life in patients with high myopia. Int Ophthalmol. 2014;34(2):171-83. DOI: 10.1007/s10792-013-9805-8.
  9. Zhu X, Meng J, Han C, Wu Q, Du Y, Qi J, et al. CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Discov. 2023;9(1):94. DOI: 10.1038/s41421-023-00588-2.
  10. Binder KW, Wrzesińska MA, Kocur J. Anxiety in persons with visual impairment. Psychiatr Pol. 2020;54(2):279-288. DOI: 10.12740/PP/OnlineFirst/85408.
  11.  Sankaridurg P, Tahhan N, Kandel H, Naduvilath T, Zou H, Frick KD, et al. IMI Impact of Myopia. Invest Ophthalmol Vis Sci. 2021;62(5):2. DOI: 10.1167/iovs.62.5.2.
  12. Ali SG, Wang X, Li P, Jung Y, Bi L, Kim J, et al. A systematic review: Virtual-reality-based techniques for human exercises and health im- provement. Front Public Health. 2023;11:1143947. DOI: 10.3389/fpubh.2023.1143947.
  13. Martínez-Albert N, Bueno-Gimeno I, Gené-Sampedro A. Risk Factors for Myopia: A Review. J Clin Med. 2023;12(18):6062. DOI: 10.3390/jcm12186062.
  14.  Tian Q, Tong P, Chen G, Deng M, Cai T, Tian R, et al. GLRA2 gene mutations cause high myopia in humans and mice. J Med Genet. 2023;60(2):193-203. DOI: 10.1136/jmedgenet-2022-108425.
  15.  Bray NJ, O’Donovan MC. The genetics of neuropsychiatric disorders. Brain Neurosci Adv. 2019;2:2398212818799271. DOI: 10.1177/2398212818799271.
  16.  Liu Y, Liu Y, Zhang W, Xue ZQ, Zhang FX, Xu WG, et al. Screening of genes interacting with high myopia and neuropsychiatric disorders. Sci Rep. 2023;13:18347. DOI: 10.1038/s41598-023-45463-y.
  17. Yokoi T, Moriyama M, Hayashi K, Shimada N, Tomita M, Yamamoto N, et al. Predictive factors for comorbid psychiatric disorders and their impact on vision-related quality of life in patients with high myopia. Int Ophthalmol. 2014;34(2):171-83. DOI: 10.1007/s10792-013-9805-8.
  18. Ministerstvo okhorony zdorovya Ukrayiny. Nakaz Ministerstva okhorony zdorovya Ukrayiny Unifikovanyy klinichnyy protokol pervynnoyi, vtorynnoyi (spetsializovanoyi), tretynnoyi (vysokospetsializovanoyi) medychnoyi dopomohy porushennya refraktsiyi ta akomodatsiyi: miopiya, hipermetropiya, astyhmatyzm, anizometropiya, presbiopiya, porushennya akomodatsiyi, ambliopiya, keratokonus, kontaktna korektsiya zoru № 827. Kyyiv: Ministerstvo okhorony zdorovya Ukrayiny; 2015. Dostupno: . [in Ukrainian].
  19. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-2194. DOI: 10.1001/jama.2013.281053.
  20. Ministerstvo okhorony zdorovya Ukrayiny. Nakaz Ministerstva okhorony zdorovya Ukrayiny Pro zatverdzhennya form pervynnoyi oblikovoyi dokumentatsiyi ta Instruktsiy shchodo yikh zapovnennya, shcho vykorystovuyutsya u zakladakh okhorony zdorovya nezalezhno vid formy vlasnosti ta pidporyadkuvannya № 110. Kyyiv: Ministerstvo okhorony zdorovya Ukrayiny; 2012. Dostupno: http://search.ligazakon.ua/l_doc2. nsf/link1/RE20974Z.html. [in Ukrainian].
  21.  Babak VP, Biletskyi AYa, Prystavka OP, Prystavka PO. (2001). Statystychna obrobka danykh; К.: MIIVTs; 2001. 388 s. [in Ukrainian].
  22. Hastie T, Tibshirani R, Friedman J. The Elements of Statistical Learning: Data Mining, Inference, and Prediction. 2-nd ed. New York: Springer; 2009. 767 p.
  23. Drozdov V. Nosogenies in patients with myopia: clinical and psychological features. USMYJ. 2025;152(1):69-76. DOI: https://doi.org/10.32345/USMYJ.1(152).2025.
  24.  Wang Y, Du R, Xie S, Chen C, Lu H, Xiong J, et al. Machine Learning Models for Predicting Long-Term Visual Acuity in Highly Myopic Eyes. JAMA Ophthalmol. 2023;141(12):1117-1124. DOI: 10.1001/jamaophthalmol.2023.4786.
  25. Drozdov V, Skrypnyk R. Hypochondriac disorders in patients with myopia: personal characteristics and their role in the formation of the internal picture of the disease. USMYJ. 2024;150(4):96-101. DOI: 10.32345/USMYJ.4(150).2024.96-101.
  26. Tedja MS, Haarman AEG, Meester-Smoor MA, Kaprio J, Mackey DA, Guggenheim JA, et al. IMI - Myopia Genetics Report. Invest Oph- thalmol Vis Sci. 2019;60(3):M89-M105. DOI: 10.1167/iovs.18-25965.
  27. Sanfilippo PG, Hewitt AW, Hammond CJ, Mackey DA. The heritability of ocular traits. Surv Ophthalmol. 2010;55(6):561-83. DOI: 10.1016/j.survophthal.2010.07.003.
  28.  Wojciechowski R, Congdon N, Bowie H, Munoz B, Gilbert D, West S. Heritability of refractive error and familial aggregation of myopia in an elderly American population. Invest Ophthalmol Vis Sci. 2005;46(5):1588-92. DOI: 10.1167/iovs.04-0740.
  29. Lyhne N, Sjølie AK, Kyvik KO, Green A. The importance of genes and environment for ocular refraction and its determiners: a population based study among 20-45 year old twins. Br J Ophthalmol. 2001;85(12):1470-6. DOI: 10.1136/bjo.85.12.1470.
  30. Dirani M, Shekar SN, Baird PN. Evidence of shared genes in refraction and axial length: the Genes in Myopia (GEM) twin study. Invest Ophthalmol Vis Sci. 2008;49(10):4336-9. DOI: 10.1167/iovs.07-1516.
  31. Meng W, Butterworth J, Malecaze F, Calvas P. Axial length of myopia: a review of current research. Ophthalmologica. 2011;225(3):127-34. DOI: 10.1159/000317072.
  32.  Zhang Z, Mu J, Wei J, Geng H, Liu C, Yi W, et al. Correlation between refractive errors and ocular biometric parameters in children and adolescents: a systematic review and meta-analysis. BMC Ophthalmol. 2023;23(1):472. DOI: 10.1186/s12886-023-03222-7. Erratum in: BMC Ophthalmol. 2023;23(1):496. DOI: 10.1186/s12886-023-03245-0.
  33. Chen X, Jiang Y, Fan Q, Li L, Lu W, Wang Y. Association of Axial Length and Refraction with Near Horizontal Heterophoria in Chinese Children: An Observational Cross-Sectional Study. J Ophthalmol. 2022;2022:7549851. DOI: 10.1155/2022/7549851.
  34. Rubin A, Evans T, Hasrod N. Dioptric power and refractive behaviour: a review of methods and applications. BMJ Open Ophthalmol. 2022;7(1):e000929. DOI: 10.1136/bmjophth-2021-000929.
  35.  Zhou F, Chen N, Qian H, Gong D, Li K. A study on the variability and correlation of ocular biological measurement parameters in adult myopic patients. Front Med (Lausanne). 2025;11:1526703. DOI: 10.3389/fmed.2024.1526703.
  36. Zhang J, Zhu Y, Yuan P, Dong X, Xie M, Ma Z, et al. Differential correlations of refractive error, axial length, and axial length-to-corneal curvature ratio with anterior segment biometrics in myopic refractive surgery candidates. Photodiagnosis Photodyn Ther. 2024;50:104408. DOI: 10.1016/j.pdpdt.2024.104408.

Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 146-163 pages, index UDC 617.753.2-036.8:519.91:616.89-008.19

DOI:

10.29254/2077-4214-2025-3-178-146-163

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