Hasanli N. G.

CHARACTERISTICS OF PERIPHERAL BLOOD PARAMETERS IN PREGNANT WOMEN WITH PREECLAMPSIA AND SODIUM HOMEOSTASIS DISORDER

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About the author:

Hasanli N. G.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Hypernatraemia, defined as an elevated serum sodium level, may occur during pregnancy and represents a significant clinical condition. Alterations in peripheral blood parameters in women with pre-eclampsia and disturbances of sodium homeostasis may reflect disease severity and carry prognostic value. The aim of the study was to assess the impact of pre-eclampsia and hypernatraemia on peripheral blood parameters. The main group consisted of 70 pregnant women with moderate to severe pre-eclampsia combined with hypernatraemia, while the control group included 45 women with an uncomplicated course of pregnancy. The investigation involved the evaluation of peripheral blood indices and serum sodium levels. In comparison with the control group, women with pre-eclampsia demonstrated elevated serum sodium levels and an increased proportion of band neutrophils in peripheral blood (PU=0.042; ANOVA=0.024; PU=0.034; ANOVA=0.048). Among patients with pre-eclampsia and hypernatraemia, Spearman’s coefficient revealed a significant inverse correlation between serum sodium and mean corpuscular volume (ρ= -0.417; p=0.000). Logistic regression analysis showed that hypernatraemia increased the risk of pre-eclampsia by 1.33 times (risk ratio = 1.33±0.06; p<0.05). Thus, pregnant women with pre-eclampsia and hypernatraemia exhibit characteristic alterations in peripheral blood, most notably a significant increase in band neutrophils. The identified association confirms the prognostic relevance of hypernatraemia in the development of pre-eclampsia.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 3,178, 129-135 pages, index UDC 618.3-008.6

DOI:

10.29254/2077-4214-2025-3-178-129-135