Kosharnyi V. V., Boyko E. M., Abdul-Ogli L. V., Tkachenko S. S., Kushnareva K. A.

CHANGES IN THE NEUROMUSCULAR COMPLEX OF THE CALF MUSCLE IN CASE OF DAMAGE TO THE BRANCHES OF THE LUMBAR AND SACRAL PLEXIS

---

Show/Download

About the author:

Kosharnyi V. V., Boyko E. M., Abdul-Ogli L. V., Tkachenko S. S., Kushnareva K. A.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

In the context of the war in Ukraine, where many wounded people face peripheral nerve injuries, experimental studies of sciatic nerve transection can help in improving surgical techniques, for example, neurorrhaphy or nerve transplantation, as well as in developing new pharmacological approaches to stimulating regeneration. The femoral nerve, in turn, provides innervation to the anterior group of thigh muscles, and its damage leads to impaired gait and stability, which is also a common problem among combat victims. The results obtained are of great importance for neurophysiology, experimental medicine and rehabilitation. They can be used in such areas as improving rehabilitation methods after peripheral nerve damage, developing approaches to electrical stimulation of denervated muscles to prevent their atrophy. Deepening knowledge about the mechanisms of neuromuscular adaptation to denervation, which may be useful in neurosurgery. The study showed that with partial neurotomy, the muscle retains significant functional activity due to residual innervation. Complete loss of innervation in the early stages leads to a sharp decrease in excitability, but even under such conditions, adaptive processes occur that maintain the basic level of chronaxy. This emphasizes the need for timely restoration of nerve connections or the use of electrical stimulation to prevent muscle tissue atrophy.

Tags:

Bibliography:

1. Lawry LL, Mani V, Hamm TE, Smith J, Brown K, Johnson R. Qualitative assessment of combat-related injury patterns and injury prevention in Ukraine since the Russian invasion. BMJ Military Health. 2025. DOI: https://doi.org/10.1136/military-2024-002863.
2. Jones PE, Meyer RM, Faillace WJ, Landau ME, Campbell WW. Combat injury of the sciatic nerve – An institutional experience. Mil Med. 2018;183(9-10):e434-e441. DOI: 10.1093/milmed/usy030.
3.  Iordache SD, Gorski A, Nahas M, Cohen R, Shapira Y. Treatment of peripheral nerve injuries in Syria’s war victims: Experience from a Northern Israeli hospital. Isr Med Assoc J. 2021;23(5):279-285.
4. Zhang S, Han G, Xiong Y, Li Q, Wang J. Characteristics and mechanism of lower limb injury induced by landmine blast: A research in a rabbit model. Ulus Travma Acil Cerrahi Derg. 2023;29(12):1335-1343. DOI: 10.14744/tjtes.2023.39560.
5. Loskutov O, Pylypenko M, Tsymbalyuk V, Kolesnyk O. War in Ukraine: A neurosurgical perspective. Neurosurg Rev. 2023;46(1):45-53. DOI: 10.1007/s10143-022-01947-8.
6. Gordon T. Peripheral nerve regeneration and muscle reinnervation. Int J Mol Sci. 2020;21(22):8652. DOI: 10.3390/ijms21228652.
7. Menorca RM, Fussell TS, Elfar JC. Nerve physiology: Mechanisms of injury and recovery. Hand Clin. 2013;29(3):317-330. DOI: 10.1016/j.hcl.2013.04.002.
8. Zhang PX, Han N, Kou YH, Zhu QT, Liu XL. Advance of peripheral nerve injury repair and reconstruction. Chin Med J (Engl). 2017;130(18):2233-2240. DOI: 10.4103/0366-6999.213959.
9. Noble J, Munro CA, Prasad VS, Midha R. Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. J Trauma Acute Care Surg. 1998;45(1):116-122. DOI: 10.1097/00005373-199807000-00025.
10. Romach MK, Rutka JT. Building healthcare capacity in pediatric neurosurgery and psychiatry in a post-Soviet system: Ukraine. World Neurosurg. 2018;111:166-174. DOI: 10.1016/j.wneu.2017.12.093.
11. Grinsell D, Keating CP. Peripheral nerve reconstruction after injury: A review of clinical and experimental therapies. Biomed Res Int. 2014;2014:698256. DOI: 10.1155/2014/698256.
12. Demeco A, Marotta N, Moggio L, Costantino C, de Sire A. Rehabilitation of patients with nerve injuries: Current approaches and perspectives. J Neurorestoratol. 2023;11:45-58. DOI: 10.26599/JNR.2023.9040005.
13. Marotta N, Demeco A, Moggio L, Ammendolia A. Peripheral nerve injuries: From mechanisms to therapeutic strategies. Neural Regen Res. 2020;15(7):1257-1265. DOI: 10.4103/1673-5374.272144.
14. Ecklund JM, Ling GS. From the battlefront: Peripheral nerve surgery in modern day warfare. Neurosurg Clin N Am. 2009;20(1):107-110. DOI: 10.1016/j.nec.2008.07.022.

Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 429-435 pages, index UDC 612.81:616-008.9:611.97/.98:611.13/.16-007.23-092.9

DOI:

10.29254/2077-4214-2025-1-176-429-435