Vesnin A. V., Karpinska O. D.
СHANGES IN CYTOKINE PROFILE IN OSTEOPATHIC NON-DRUG TREATMENT OF TENSION HEADACHE
Show/Download
About the author:
Vesnin A. V., Karpinska O. D.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
Dysfunction of the neck and shoulder girdle muscles often causes tension headache (TH), caused by mechanical stress and inflammatory processes in the tissues. Reduced blood supply to the brain is accompanied by the development of an inflammatory response (IL-6) and increased expression of IL-10 and TNF-α genes. A special treatment complex of osteopathic techniques has been developed to eliminate muscle tension and restore normal blood circulation, effectively reducing pain's mechanical causes. The aim of the study is to show the mechanism of formation of the response of proinflammatory cytokines (IL-6, IL-10, TNF-α) to muscle dysfunction and their response to osteopathic correction and to analyze changes in proinflammatory cytokines in patients before and after treatment. A statistical analysis was conducted comparing the levels of indicators before and after treatment. Forty-eight people aged 23 to 59 were examined. The levels of cytokines IL-6, IL-10, and TNF-α were measured before and 3-5 days after treatment. The study shows that an increase in cytokine levels is observed in TH and decreases after the causes are eliminated. In the first stages, there is an increase in cytokine levels, but during treatment, they gradually normalize. The complex process of action of proinflammatory cytokines, which react to any inflammatory processes in the body, does not give an unambiguous answer regarding the choice of cytokines as markers responsible for the formation of tension headache. Anti-inflammatory cytokines may be markers of the inflammatory process in the muscles responsible for the formation of TH, but the long process of normalizing their levels has not shown a clear trend toward reducing inflammation.
Tags:
Bibliography:
- Saylor D, Steiner TJ. The global burden of headache. Semin Neurol. 2018;38(2):182-190. DOI: 10.1055/s-0038-1646946.
- Bodhankar S, Chen Y, Vandenbark AA, Murphy SJ, Offner H. IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke. Metab Brain Dis. 2013;28(3):375-86. DOI: 10.1007/s11011-013-9413-3.
- Guo Z, Wu HT, Li XX, Yu Y, Gu RZ, Lan R, et al. Edaravone protects rat astrocytes from oxidative or neurotoxic inflammatory insults by restoring Akt/Bcl-2/Caspase-3 signaling axis. IBRO Rep. 2020;8:122-128. DOI: 10.1016/j.ibror.2020.04.003.
- Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. DOI: 10.1177/0333102417738202.
- Dembic Z. The Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response. 1st ed. London: Academic Press; 2015. 320 p.
- Duan YW, Chen SX, Li QY, Zang Y. Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-α-Necroptosis Pathway. Int J Mol Sci. 2022;23(13):7191. DOI: 10.3390/ijms23137191.
- Rambe AS, Sjahrir H, Machfoed MH. Tumour Necrosis Factor-Α, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration. Open Access Maced J Med Sci. 2017;5(1):54-57. DOI: 10.3889/oamjms.2017.024.
- Musubire AK, Cheema S, Ray JC, Hutton EJ, Matharu M. Cytokines in primary headache disorders: a systematic review and metaanalysis. J Headache Pain. 2023;24(1):36. DOI: 10.1186/s10194-023-01572-7.
- Thuraiaiyah J, Erritzøe-Jervild M, Al-Khazali HM, Schytz HW, Younis S. The role of cytokines in migraine: a systematic review. Cephalalgia. 2022;42(14):1565-1588. DOI: 10.1177/03331024221118924.
- Zheng T, Zeng N, Li G, Lin S, Yu B, Yuan J, et al. Causal relationship between primary headache mediated by circulating cytokines and cerebral cortex structure: a mediation Mendelian randomization study. Cereb Cortex. 2024;34(9):bhae349. DOI: 10.1093/cercor/bhae349.
Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 163-173 pages, index UDC 616.839.11-085.828-078
