Bukreieva Yu. V., Kalbus O. I.

ANXIETY, DEPRESSION AND SOMATIC COMORBID CONDITIONS IN MIGRAINE AND TENSION-TYPE HEADACHE

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About the author:

Bukreieva Yu. V., Kalbus O. I.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Migraine and tension-type headache are the most common types of primary headache in the world. Headache, as a symptom, can occur in several different somatic diseases, namely primary headaches are a separate nosological unit that can exist against the background of other comorbid pathologies. Determining the comorbidity of primary headache is an urgent problem, with a view to the influence of conditions on each other, predicting the course and impact on patients' quality of life. Our study provides a comprehensive description of the main comorbidities in chronic migraine and chronic tension-type headache. The study involved 79 people who were divided into three groups: patients with chronic migraine, patients with chronic tension-type headache, and a control group that had no more than two headache episodes during the year before the examination. During the clinical and anamnestic examination, the following comorbid pathologies were identified: epilepsy, endocrinological disorders, gastrointestinal pathology, arterial hypertension, hypercholesterolemia, anxiety and depression, chronic back pain. We found that the presence of comorbid pathology was more often recorded in the headache patient groups than in the control group. A comorbid relationship was determined between chronic migraine and epilepsy, as well as anxiety and depression. Gastrointestinal pathology was more common in patients with chronic migraine with aura, compared with the chronic migraine without aura group. Chronic back pain and arterial hypertension were comorbid conditions in both groups of patients, but in the chronic tension-type headache group they were more common. These comorbid conditions have a bidirectional relationship with primary headache and may influence the course of each other. Therefore, studying the comorbidity of migraine and chronic tension-type headache may provide useful information for predicting the course of primary headache.

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Bibliography:

1. Moltó A, Dougados M. Comorbidity indices. Clin Exp Rheumatol. 2014;32(5(85)):S-131-4.
2. Caponnetto V, Deodato M, Robotti M, Koutsokera M, Pozzilli V, Galati C, et al. Comorbidities of primary headache disorders: a literature review with meta-analysis. J Headache Pain. 2021;22(1):71. DOI: 10.1186/s10194-021-01281-z.
3. Onan D, Younis S, Wellsgatnik WD, Farham F, Andruškevičius S, Abashidze A, et al. Debate: differences and similarities between tensiontype headache and migraine. J Headache Pain. 2023;24(1):92. DOI: 10.1186/s10194-023-01614-0.
4. Tachibana H. [Comorbidity in migraine]. Rinsho Shinkeigaku. 2022;62(2):105-111. DOI: 10.5692/clinicalneurol.cn-001698.
5. Olesen J. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1-211.
6. Hruzieva TC, Liehan VM, Ogniev VA, Нaliien-ko LI, Kriachkova LV, Palamar BI, et al. Biostatystyka. Vinnytsia: Nova knyha; 2020. 384 s. [in Ukrainian].
7. Paungarttner J, Quartana M, Patti L, Sklenárová B, Farham F, Jiménez IH, et al. Migraine – a borderland disease to epilepsy: near it but not of it. J Headache Pain. 2024;25(1):11. DOI: 10.1186/s10194-024-01719-0.
8. Zhang S, Li J, Zhou D. A comparison of comorbid headache between patients with temporal lobe epilepsy and juvenile myoclonic epilepsy. Sci Rep. 2023;13(1):16962. DOI: 10.1038/s41598-023-43705-7.
9. Engstrand H, Revdal E, Argren MB, Hagen K, Zwart JA, Brodtkorb E, et al. Relationship between migraine and epilepsy in a large population-based cohort: The HUNT Study. Eur J Neurol. 2024;31(12):e16496. DOI: 10.1111/ene.16496.
10. Atalar AÇ, Özge A, Türk BG, Ekizoğlu E, Kurt Gök D, Baykan B, et al Diagnosis of comorbid migraine without aura in patients with idiopathic/genetic epilepsy based on the gray zone approach to the International Classification of Headache Disorders 3 criteria. Front Neurol. 2023;13:1103541. DOI: 10.3389/fneur.2022.1103541.
11. Ashina S, Bendtsen L, Lyngberg AC, Lipton RB, Hajiyeva N, Jensen R. Prevalence of neck pain in migraine and tension-type headache: a population study. Cephalalgia. 2015;35(3):211-9. DOI: 10.1177/0333102414535110.
12. Yoon MS, Manack A, Schramm S, Fritsche G, Obermann M, Diener HC, et al. Chronic migraine and chronic tension-type headache are associated with concomitant low back pain: results of the German Headache Consortium study. Pain. 2013;154(3):484-492. DOI: 10.1016/j.pain.2012.12.010.
13. Al-Khazali HM, Younis S, Al-Sayegh Z, Ashina S, Ashina M, Schytz HW. Prevalence of neck pain in migraine: A systematic review and meta-analysis. Cephalalgia. 2022;42(7):663-673. DOI: 10.1177/03331024211068073.
14. Gipponi S, Venturelli E, Rao R, Liberini P, Padovani A. Hypertension is a factor associated with chronic daily headache. Neurol Sci. 2010;31(1):S171-3. DOI: 10.1007/s10072-010-0322-5.
15. McCracken HT, Thaxter LY, Smitherman TA. Psychiatric comorbidities of migraine. Handb Clin Neurol. 2024;199:505-516. DOI: 10.1016/ B978-0-12-823357-3.00013-6.
16. Martami F, Ghorbani Z, Abolhasani M, Togha M, Meysamie A, Sharifi A, et al. Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran. Neurol Sci. 2018;39(1):63-70. DOI: 10.1007/s10072-017-3141-0.
17. Kalra S, Verma S, Kapoor N. Headache in diabetes. J Pak Med Assoc. 2024;74(10):1884-1885. DOI: 10.47391/JPMA.24-82.
18. Fernández-Garza LE, Marfil A. Comorbidity between hypothyroidism and headache disorders in a Mexican population. Rev Neurol. 2022;75(1):13-16. DOI: 10.33588/rn.7501.2022054.

Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 154-162 pages, index UDC 616.857+616.831-009: 454-092.11+ 616-06

DOI:

10.29254/2077-4214-2025-1-176-154-162