Rymar А. А., Nebesna Z. M.

FEATURES OF ULTRASTRUCTURAL CHANGES IN THE ALVEOLAR WALL OF THE RESPIRATORY PORTION OF THE LUNGS UNDER CONDITIONS OF CHRONIC ENDOGENOUS NEOPLASTIC INTOXICATION AND CORRECTIVE EFFECT OF Au/Ag/Fe NANOPARTICLES COMPOSITION

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About the author:

Rymar А. А., Nebesna Z. M.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

It is known that gastrointestinal cancer is one of the leading causes of cancer-related deaths worldwide. Colorectal cancer is the most common among tumors and tends to have a high rate of spread. Respiratory disorders include a wide range of diseases affecting the respiratory system, particularly the lungs. Therefore, it is important to study the relationship between these disorders and neoplastic processes in the body. With the development of nanotechnology and the improvement of its safety, nanoparticles can become an important tool in the fight against cancer. The promise of their use lies in their ability to be modified so that they selectively target tumor cells. The aim of the study was to investigate the submicroscopic restructuring of alveoli in respiratory portion of the lung in the modeled DMH-induced colon adenocarcinoma in situ, to evaluate the use of Au/Ag/Fe nanoparticles composition for the correction of ultrastructural disorders of respiratory alveoli in the development of induced carcinogenesis. Electron microscopic studies of the alveoli of the respiratory portion of the lung revealed that the modeled carcinogenesis induced by DMH causes deep damage to the submicroscopic organization of the components of the blood-air barrier, respiratory and secretory alveolocytes, and alveolar macrophages. The use of nanoparticles in induced oncogenesis as a corrective factor had a positive effect on regenerative processes and contributed to the restoration of the ultrastructure of nuclei and cytoplasmic components of alveolar wall cells, which improves their functioning and, consequently, the normal course of gas exchange.

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Bibliography:

1. Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. Int J Mol Sci. 2017;18(1):197. DOI: 10.3390/ ijms18010197.
2. Brody H. Colorectal cancer. Nature. 2015;521(7551):S1. DOI: 10.1038/521S1a.
3. Kuipers EJ, Grady WM, Lieberman D, Seufferlein T, Sung JJ, Boelens PG, et al. Colorectal cancer. Nat Rev Dis Primers. 2015;1:15065. DOI: 10.1038/nrdp.2015.65.
4. Doskaliuk BV, Zaiats LM. Ultrastrukturni osoblyvosti alveolotsytiv I ta II typiv pry eksperymentalnomu modeliuvanni systemnoi sklerodermii ta pry yii korektsii. Ukrainskyi rematolohichnyi zhurnal. 2023;92(2):16-20. DOI: 10.32471/rheumatology.2707-6970.92.17801. [in Ukrainian].
5. Di Stefano A. Nanotechnology in Targeted DrugDelivery. Int J Mol Sci. 2023;24(9):8194. DOI: 10.3390/ijms24098194.
6. Yusuf A, Almotairy ARZ, Henidi H, Alshehri OY, Aldughaim MS. Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems. Polymers. 2023;15(7):1596. DOI: 10.3390/ polym15071596.
7. Тhwala LN, Ndlovu SC, Mpofu KT, Lugongolo MY, Mthunzi-Kufa P. Nanotechnology – Based Diagnostics for Diseases Prevalent in Developing Countries: Current Advances in Point-of-Care Tests. Nanomaterials. 2023;13(7):1247. DOI: 10.3390/nano13071247.
8. Wang Y, Yu L, Kong X, Sun L. Application of nanodiagnostics in point-of-care tests for infectious diseases. Int J Nanomedicine. 2017;12:4789-4803. DOI: 10.2147/IJN.S137338.
9. Davis ME, Chen ZG, Shin DM. Nanoparticletherapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008;7(9):771- 82. DOI: 10.1038/nrd2614.
10. Tian H, Zhang T, Qin S, Huang Z, Zhou L, Shi J, et al. Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. J Hematol Oncol. 2022;15(1):132. DOI: 10.1186/s13045-022-01320-5.
11. Perše M, Cerar A. Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats. J Biomed Biotechnol. 2011;2011:473964. DOI: 10.1155/2011/473964.
12. Horalskyi LP, Khomych VT, Kononskyi OI. Osnovy histolohichnoi tekhniky i morfofunktsionalnimetody doslidzhen u normi ta pry patolohii. Zhytomyr: Polissia; 2011. 288 s. [in Ukrainian].
13. Lytvyniuk DV, Klishch IM, Dovbush AV, Nebesna ZM, Havryliuk-Skyba HO. Ultrastrukturni zminy respiratornykh alveolotsytiv v dynamitsi pislia eksperymentalnoi termichnoi travmy. Zdobutky klinichnoi i eksperymentalnoi medytsyny. 2022;(2):95-9. DOI: 10.11603/1811- 2471.2022.v.i2.13138. [in Ukrainian].
14. Zaiats LM, Klishch IP. Ultrastructure of alveolar macrophages in case of experimental acute renal failure. World of medicine and biology. 2018;1(63):130-133.DOI: 10.26.724/2079-8334-2018-1-63-130-133.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 579-589 pages, index UDC 616.24-091.8:616-008.6-036.12-08:546.57/.59/.72-022.532]-092.9

DOI:

10.29254/2077-4214-2024-4-175-579-589