Galatenko N. A., Vislohuzova T. V., Rozhnova R. A., Narazhayko L. F.

PERSPECTIVE COMPOSITE MATERIAL BASED ON EPOXYPOLYURETHANE WITH A PROLONGED ACTION OF FERROCENE FOR MEDICINE

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About the author:

Galatenko N. A., Vislohuzova T. V., Rozhnova R. A., Narazhayko L. F.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The development of implant materials for bone tissue with improved physical-mechanical, and biological characteristics remains a relevant task in the field of creating polymeric materials for medical use. Therefore, the goal of our work was to create a polymer composites based on epoxypolyurethane (EPU) with ferrocene as a filler to obtain a material with improved physical-mechanical, and biological characteristics for medical use. Using tissue culture and fibroblasts, the concentration of the biologically active substance was determined, which, as part of the polymer carrier, does not lead to toxic effects. It was found that a 0.001% ferrocene solution had a stimulating effect in the early stages of cultivation, compared to the control, and also slowed down the cell degeneration process on the 10th day of the study. The physical-mechanical properties of fumarate-containing epoxy-polyurethanes depend not only on the presence of ferrocene in their composition but also on its concentration, allowing the creation of polymer materials with specified characteristics. According to the results of spectrophotometric studies, it was established that the studied composites are capable of prolonged release of ferrocene from the polymer matrix of the tested composites. The amount of ferrocene released over 30 days constitutes 53% of the total introduced filler amount. Thus, the introduction of a biologically active substance into the epoxy-polyurethane polymer matrix enables the creation of implants based on them, which can be used not only for bone fixation but also for therapeutic purposes.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 288-298 pages, index UDC 678.664:678.686:617.5

DOI:

10.29254/2077-4214-2024-4-175-288-298