Kosharnyi V. V., Kagramanyan A. K., Abdul-Ogly L. V., Ruthaizer V. G., Demchenko O. M.
MICROSCOPIC CHANGES IN NEPHRON STRUCTURES OF RENAL TISSUE FOLLOWING BLAST-INDUCED EXPERIMENTAL TRAUMA
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About the author:
Kosharnyi V. V., Kagramanyan A. K., Abdul-Ogly L. V., Ruthaizer V. G., Demchenko O. M.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
Our study shows that pressure waves significantly affect the structural and functional activity of the kidney, especially in the acute and early stages after exposure. Damage was mainly observed to the nephron and its components, including the renal corpuscle and the proximal and distal tubular system. However, in later stages, these injuries became more irreversible and were characterized by a destructive and sclerotic process in some areas of the renal parenchyma. Under conditions simulating blast waves, we observed that animals developed more pronounced disorders in the acute phase of exposure, such as edema and massive hemorrhage, which could be stabilized to prevent further complications. This provides a theoretical basis for possible emergency interventions after blast waves, which were the etiological factor of renal injury in our study. In the early stage after trauma, edema was slightly reduced, but hemorrhage was more severe and extensive. At later stages after exposure to pressure waves, we observed areas of dystrophic necrotic changes of tubular epithelium in the renal parenchyma, which made necrotic areas visible, and the degenerative and destructive processes intensified in the renal parenchyma. Thus, according to the results of the experimental study, the most significant morphological and histochemical changes in tissue and structural components appeared in the acute phase (first day) and early phase (seventh day) after pressure wave exposure, but at later stages (fourteenth day) these phenomena and manifestations became irreversible in some areas.
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 289-298 pages, index UDC 616–001.18:616.12–008.6:576.31:616–091–092.9
