Kubrak M. A., Zavgorodnii S. M., Danilyk M. B.

EVALUATION OF THE RESULTS OF USING ENDOSCOPIC METHODS AS THE FIRST STAGE OF TREATMENT OF PATIENTS WITH COMPLICATED FORMS OF COLON CANCER

---

Show/Download

About the author:

Kubrak M. A., Zavgorodnii S. M., Danilyk M. B.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The use of endoscopic methods for the treatment of patients with complicated forms of large intestine cancer remains a controversial issue. The study aimed to evaluate the results of using endoscopic methods as the first stage of treatment of patients with complicated forms of colon cancer. The study group included 180 (100%) patients with complicated forms of colon cancer. In the comparison group, colonoscopy was performed in 11 (15.49%) patients, and in the main group - in 83 (76.15%) patients, U=38.0; p=0.0019. Stable haemostasis was achieved in 7 (8.43%) patients of the main group with acute intestinal bleeding; in 31 (37.35%) patients with acute intestinal obstruction, tumour tunnelling was performed, and in 7 (8.43%) patients, a self-expanding metal stent was placed. Another 9 (10.84%) patients achieved the partial restoration of the passage; in 15 (18.07%) patients, the procedure was unsuccessful and in 12 (14.46%), it resulted in complications. Endoscopic examination of the large intestine has increased the number of postponed surgeries and the proportion of primary radical surgical interventions. It has also reduced the number of surgeries that resulted in colostomy.

Tags:

Bibliography:

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. DOI: https://doi.org/10.3322/ caac.21660.
2. Bielikova IV, Khorosh MV, Radchenko NR, Lyakhova NA. State of organization of providing oncological medical care to the population of Ukraine. Pol Merkur Lekarski. 2023;51(6):638-645. DOI: https://doi.org/ 10.36740/Merkur202306110.
3. Spannenburg L, Sanchez Gonzalez M, Brooks A, Wei S, Li X, Liang X, et al. Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials. Eur J Surg Oncol. 2020;46(8):1404-1414. DOI: https://doi.org/10.1016/j.ejso.2020.04.052.
4. Johnston A, Kelly SE, Hsieh SC, Skidmore B, Wells GA. Systematic reviews of clinical practice guidelines: a methodological guide. J Clin Epidemiol. 2019;108:64-76. DOI: https://doi.org/10.1016/j.jclinepi.2018. 11.030.
5. Pavlidis ET, Galanis IN, Pavlidis TE. Management of obstructed colorectal carcinoma in an emergency setting: An update. World J Gastrointest Oncol. 2024;16(3):598-613. DOI: https://doi.org/10.4251/wjgo.v16.i3.598.
6. Otani K, Kawai K, Hata K, Tanaka T, Nishikawa T, Sasaki K, et al. Colon cancer with perforation. Surg Today. 2019;49(1):15-20. DOI: https://doi.org/10.1007/s00595-018-1661-8.
7. Mauro A, Scalvini D, Borgetto S, Fugazzola P, Mazza S, Perretti I, et al. Malignant Acute Colonic Obstruction: Multidisciplinary Approach for Endoscopic Management. Cancers (Basel). 2024;16(4):821. DOI: https://doi.org/10.3390/cancers16040821.
8. Zeng K, Zhang F, Yang H, Zha X, Fang S. Laparoscopic versus open surgery in obstructive colorectal cancer patients following stents placement: a comprehensive meta-analysis of cohort studies. Surgical Endoscopy. 2024;38(4):1740-1757. DOI: https://doi.org/10.1007/ s00464-024-10710-4.
9. van Hooft JE, Veld JV, Arnold D, Beets-Tan RGH, Everett S, Götz M, et al. Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2020. Endoscopy. 2020;52(5):389-407. DOI: https://doi.org/10. 1055/a-1140-3017.
10. Vogel JD, Felder SI, Bhama AR, Hawkins AT, Langenfeld SJ, Shaffer VO, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer. Dis Colon Rectum. 2022;65(2):148-177. DOI: https://doi.org/10.1097/ DCR.0000000000002323.
11. Argilés G, Tabernero J, Labianca R, Hochhauser D, Salazar R, Iveson T, et al. Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(10):1291-1305. DOI: https://doi.org/10.1016/j.annonc.2020.06.022.
12. Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, et al. Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021;19(3):329-359. DOI: https://doi.org/10.6004/jnccn.2021.0012.
13. Seo SY, Kim SW. Endoscopic Management of Malignant Colonic Obstruction. Clin Endosc. 2020;53(1):9-17. DOI: https://doi.org/10.5946/ ce.2019.051.
14. Sarani B, Paspulati RM, Hambley J, Efron D, Martinez J, Perez A, et al. A multidisciplinary approach to diagnosis and management of bowel obstruction. Curr Probl Surg. 2018;55(10):394-438. DOI: https://doi.org/10. 1067/j.cpsurg.2018.09.001.
15. Sengupta N, Feuerstein JD, Jairath V, Shergill AK, Strate LL, Wong RJ, et al. Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline. Am J Gastroenterol. 2023;118(2):208-231. DOI: https://doi.org/10.14309/ajg.0000000000002130.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 149-157 pages, index UDC 616.345-006.6-06-085/-089-072.1

DOI:

10.29254/2077-4214-2024-3-174-149-157