Pivtorak V. I., Verkholantsev D. S.

POTENTIAL APPLICATIONS OF PLATELET-RICH AUTOLOGOUS PLASMA FOR PERIPHERAL NERVE REGENERATION IN UPPER EXTREMITY TRAUMATIC INJURIES

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About the author:

Pivtorak V. I., Verkholantsev D. S.

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LITERATURE REVIEWS

Type of article:

Scientific article

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Ukraine is currently experiencing a surge in limb injuries due to occupational accidents, traffic collisions, and, more recently, mine-blast injuries resulting from the ongoing conflict. In the rehabilitation of these injuries, peripheral nerve regeneration is of paramount importance. Traditional surgical techniques such as neurolysis and neurorrhaphy often fall short of providing optimal outcomes and may result in the loss of a portion of the nerve trunk. The problem of nerve regeneration remains a pressing issue, necessitating the exploration of novel approaches to optimize the treatment of limb injuries. To accelerate nerve repair, factors that promote nerve growth are required. Platelet-rich plasma, with its ability to stimulate cell proliferation, has emerged as a potential candidate to expedite tissue regeneration. The application of PRP has garnered increasing attention within the neurosurgical community. This article delves into the properties of plasma and analyzes current methods of its utilization for tissue regeneration. The mechanism underlying the accelerated regenerative effects on damaged tissues is attributed to the properties of platelets. Experimental and clinical studies have demonstrated the significant potential of platelets. Furthermore, platelet-rich plasma has been shown to stimulate nerve cell growth, enhance angiogenesis, reduce inflammation, and improve functional recovery following peripheral nerve injury. However, a comprehensive understanding of the impact of activated plasma on peripheral nerve regeneration remains elusive. The influence of platelet-rich plasma on peripheral nerve regeneration in the context of traumatic muscle injuries warrants further investigation and elucidation.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 70-76 pages, index UDC 616.8-091.933-085.2/.3

DOI:

10.29254/2077-4214-2024-3-174-70-76