Ostrovska S. S., Dyudun A. D., Shevchenko I. F., Agarkov S. F., Fedchenko M. P., Rodionov V. K., Bashta I. G.

CALCIUM AS AN EXOGENOUS FOOD SUPPLEMENT IN CADMIUM-INDUCED STRESS

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About the author:

Ostrovska S. S., Dyudun A. D., Shevchenko I. F., Agarkov S. F., Fedchenko M. P., Rodionov V. K., Bashta I. G.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

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Heavy metal cadmium (Cd) toxicity is a real problem in industrialised and predominantly rapidly industrialised countries due to the steady pace of industrial activity, one of the primary sources of pollution that has been steadily increasing over the decades. Changes caused by Cd lead to pathological changes in many organ systems of living organisms. The metal accumulation in tissues causes disturbances in haematological and biochemical parameters and damage to the liver, kidneys, bones, nervous tissue, etc. Understanding how Cd affects living systems allows us to develop new ways to protect organisms from its toxicity. This review focuses on calcium (Ca) and its compounds, which can be used as an exogenous food supplement to protect organisms from Cd-induced stress due to its chemical similarity to Ca. It was shown that Ca-based additives have great potential for producing rice grains with low Cd content. Assessment of the protective effect of Ca on the skeleton against bone damage is useful in assessing the health risks associated with Cd. Ca exposure is able to restore the Cd-inhibited autophagy flux and reduce Cd-induced apoptosis in kidney cells. The combined addition of Ca and vitamin D to the diet significantly reduces Cd levels in serum and tissues, and inflammatory and oxidative markers in the liver suggest that simultaneous treatment with vitamins D and Ca protects organisms from Cd hepatotoxicity.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 63-70 pages, index UDC 612.014.46:546.48:616-085:577.161.546.41

DOI:

10.29254/2077-4214-2024-3-174-63-70