THE EFFECTIVENESS OF EXERCISE APPLICATION IN GENETICALLY PREDISPOSED OBESITY AND DIABETES

  2. 2024
  3. THE EFFECTIVENESS OF EXERCISE APPLICATION IN GENETICALLY PREDISPOSED OBESITY AND DIABETES

Mazur Yu. Yu, Ilyin V. M., Pastukhova V. A., Drozdovska S. B.

THE EFFECTIVENESS OF EXERCISE APPLICATION IN GENETICALLY PREDISPOSED OBESITY AND DIABETES

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About the author:

Mazur Yu. Yu, Ilyin V. M., Pastukhova V. A., Drozdovska S. B.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

The article is dedicated to the search for molecular-genetic markers that influence the effectiveness of exercises on anthropometric and biochemical parameters, as well as body composition in cases of obesity and diabetes. The present review aims to investigate the impact of health related exercise programs on metabolism in genetically predisposed obesity and diabetes and to identify genetic predictors of effective exercise application. The study analyzes the contribution of genetic factors to the development of obesity and diabetes, as well as the underlying mechanisms. It explores the molecular basis for the occurrence of monogenic and polygenic obesity, as well as type I and type II diabetes. The article provides a list of genes responsible for obesity and diabetes. This review highlights the most significant findings from the epigenetic factors involved in the development and predisposition to obesity and diabetes, such as the effects of exercise and nutrients, and their mechanisms. The article discusses the heterogeneity of the organism's response to exercise and the possibility of predicting the effect of exercise for weight correction and normalization of metabolic parameters. Although different studies vary in the list of candidate genes involved in the response to physical activity and in the other approaches of obesity correction, only 24 genetic markers of fat loss effectiveness in response to exercises have been identified, most of which were discovered through candidate gene studies.

Tags:

diabetes, exercise, gene polymorphism, health-related fitness, molecular-genetic markers, obesity

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 36-49 pages, index UDC 575.162 + 575.167

DOI:

10.29254/2077-4214-2024-3-174-36-49

2024 Issue 3, 174
diabetes exercise gene polymorphism health-related fitness molecular-genetic markers obesity
04.10.2024
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