Hnatyuk M. S., Cholach S. Yu., Tatarchuk L. V., Stets N. Ya.

AGE CHANGES IN MASOMETRICAL PARAMETERS OF HEART PARTS IN EXPERIMENTAL ANIMALS WITH COBALT INTOXICATION

---

Show/Download

About the author:

Hnatyuk M. S., Cholach S. Yu., Tatarchuk L. V., Stets N. Ya.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

Cardiovascular disease is a significant medical and social problem today. Despite the progress in the diagnosis, correction and prevention of heart disease, morphologists and clinicians continue to study the structure and function of the heart. We studied the mass parameters of heart parts of 120 laboratory mature white male rats, which were divided into four groups. The first group consisted of 30 intact six-month-old experimental animals, the second group consisted of 30 similar 24-month-old male laboratory rats, the third group consisted of 30 six-month-old experimental animals injected with cobalt chloride, and the fourth group consisted of 30 24-month-old rats with cobalt chloride intoxication. The chemical agent was administered daily intragastrically to rats at 4 mg/kg for 30 days. The animals were euthanised by bleeding under thiopental anaesthesia. Mass parameters of the left and right ventricles and atria, interventricular and atrial septa, and the ratio between the masses of the heart chambers were determined. Quantitative data were processed statistically. It was found that the intoxication of experimental animals with cobalt chloride led to uneven, disproportionate hypertrophy of heart parts, accompanied by an increase in their mass parameters. The administration of cadmium chloride to experimental animals led to a dominant rise in the mass of the left ventricle and left atrium in 24-monthold rats, which was confirmed by a decrease in the ventricular index by 9.6%, an increase in the Fulton index by 6.0%, and an increase in the atrial index by 4.3%. The studies conducted and the results obtained indicate that intoxication of laboratory white male rats with cobalt chloride leads to an uneven, disproportionate increase in the masses of heart parts. This is confirmed by the rise in the mass parameters of the ventricles and atria, Fulton and atrial indices, and a decrease in the ventricular index. The most pronounced mass changes dominated the left ventricle and left atrium of 24-month-old experimental animals.

Tags:

Bibliography:

1. Sataieyva TP, Zadnipryany IV, Zukov W. Toxic cardiac effect of cobalt chloride excessive chronic consumption in male Wistar rats. Ecological question. 2019;3:25-32. DOI: 10.12775/EQ.2019.016.
2. Akin I, Nienaber С. Prediction of aortic dissection. Heart. 2020;106(12):870-871. DOI: https://doi.org/10.1136/heartjnl-2020-316617.
3. Amzulescu M, Slavich M, Florian A, Goetschalckx K. Does two-dimensional image reconstruction from three-dimensional full volume echocardiography improve the assessment of left ventricular morphology and function? Echocardiography. 2013;30:55-63.
4. Kuzyk YuI. Features of the pathomorphological structure of the aterosclerotic plaques of carotid atherosclerosis. Pathologia. 2019;3:355- 361. DOI: https://doi.org/10.14739/2310-1237.2019.3.188872.
5. Vlasiuk TI, Zhurakivska OY. Prospects for the use of exenatide in the correction of experimental diabetic cardiomyopathies. The Pharma Innovation Journal. 2018;7(9):35-40.
6. Mishalov VD, Tverdokhlib IV, Yurchenko VT. Pravove ta zakonodavche obhruntuvannia poriadku vyluchennia biolohichnykh obiektiv vid trupa liudyny dlia naukovykh doslidzhen z anatomii, histolohii, tsytolohii. Morphologia. 2016;10(1):107-110. [in Ukrainian].
7. Hnatjuk MS, Monastyrska NYa, Gdanska NM, Tatarchuk LV., Yasinovskyi OB. Morfometrychna otsinka osoblyvostei remodeliuvannia arterii shlunochkiv sertsia v umovakh postrezektsiinoi portalnoi hipertenzii. Visnyk medychnykh i biolohichnykh doslidzhen. 2022;1:14-16 DOI: https://doi.org/10.11603/bmbr.2706-6290.2022.1.12815. [in Ukrainian].
8. Gdanska NYa, Hnatiuk MS, Tatarchuk LV, Konovalenko SO, Tsytsiura RI. Masometrychna kharakterystyka kamer sertsia pry postrezektsiinii portalnii hipertenzii. Zdobutky klinichnoi i eksperymentalnoi medytsyny. 2021;3:63-67. DOI: https://doi.org/10.11603/1811-2471.2021.v.i3.12509. [in Ukrainian].
9. Bahrii MM, Dibrova VA, Popadynets OH, Hryshchuk MI. Metodyky morfolohichnykh doslidzhen. Vinnytsia: Nova knyha; 2016. 328 s. [in Ukrainian].
10. Festing M, Nevalainen T. The design and statistical analysis of animal experiments introduction to this issue. Ilar J. 2014;55(3):379-372.
11. Zaporozhan VM, Ariaiev ML. Bioetyka i biobezpeka. Kyiv: Zdorov҆ ia; 2013. 456 s. [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 2, 173, 367-373 pages, index UDC 616.36-089.87-06.616-91]-092.9

DOI:

10.29254/2077-4214-2024-2-173-367-373