Gresko N. I., Kyryk H. A., Bekesevych A. M., Podolyuk M. V., Tanchyn I. A.

CHANGES IN ENDOTHELIAL CELLS OF THE HEMOMICROCIRCULATORY BED OF THE COLON AT THE SUBMICROSCOPIC LEVEL UNDER CONDITIONS OF PROLONGED EXPOSURE TO OF NALBUPHINE IN THE EXPERIMENT

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About the author:

Gresko N. I., Kyryk H. A., Bekesevych A. M., Podolyuk M. V., Tanchyn I. A.

Heading:

PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

Type of article:

Scientific article

Annotation:

The research is about the prolonged exposure to the nalbuphine (opioid) on the endotheliоcytes of the vessels of the haemomicrocirculatory bed of colon at the submicroscopic level. The results of the investigation show that the prolonged opioids exposure leads to disorganization of endotheliocytes at the submicroscopic level already after 2 weeks of the experiment and grew over the next periods of the investigation. Specifically, we observed enlarged, irregularly shaped of endotheliocytes nuclei, their cytoplasm swollen and organelles are damaged in it, the basement membrane thickened, that plays an important role in the interruption of the blood supply to examined organ and development of intestinal pathology.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 2, 173, addition, 24-26 pages, index UDC 611.348:611.16].018.74:615.212.7

DOI:

10.29254/2523-4110-2024-2-173/addition-24-26