Nakonechna O. A., Kyslov O. V.

THE ROLE OF PRO-INFLAMMATORY CYTOKINES IN RATS AFTER IMPLANTATION OF POLYPROPYLENE SURGICAL MESH WITH A COATING BASED ON TANTALUM AND ITS DERIVATIVES

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About the author:

Nakonechna O. A., Kyslov O. V.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Since the early 2000s, polypropylene has become the main material used in hernia repair. However, negative statistics regarding the development of the inflammatory process after implantation of surgical meshes made of different materials still remain disappointing. The development of the inflammatory process after implantation of polypropylene surgical meshes is observed in 30-40% of patients. These data force scientists all over the world to continue the search for the optimal surgical mesh according to the chemical composition, which would suit specialists not only from the side of the physical properties of the surgical mesh, but also from the side of its biocompatible and anti-inflammatory properties. In recent years, tantalum has been successfully used to produce biocompatible medical implants in surgery, orthopedics, and orthodontics. The aim of our study was to determine the content of IL-1β and IL-6 in the blood plasma of experimental animals 28 days after implantation of polypropylene surgical meshes with a coating based on tantalum and its derivatives, in particular tantalum oxide and nitride. The experimental groups included 40 male rats of the WAG population. A 15x15mm polypropylene surgical mesh with different types of coatings was implanted between the abdominal wall and the colon with the help of surgery. 28 days after surgery, blood was collected to determine the content of IL-1β and IL-6. The data obtained after the conducted studies indicate that coatings made of tantalum and tantalum oxide do not contribute to the occurrence of the inflammatory process in comparison with the results of a group of experimental animals that were implanted with a surgical mesh without a coating. Coatings based on tantalum and tantalum oxide demonstrated excellent anti- inflammatory effects and demonstrated excellent biocompatibility, which indicates to us the possibility of further improvement of surgical meshes by applying biocompatible coatings to achieve better results in surgical practice.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 203-208 pages, index UDC 616-74:615.462:678.742.3:57.084

DOI:

10.29254/2077-4214-2024-1-172-203-208