Smirnov I. V., Nasibullin B. А., Gushcha S. G.

DETERMINING THE STATE OF THE STRUCTURAL-FUNCTIONAL CONTINUUM OF THE KIDNEY UNDER THE INFLUENCE OF NATURAL MINERAL WATER WITH INCREASED CONTENT OF ORGANIC SUBSTANCES

---

Show/Download

About the author:

Smirnov I. V., Nasibullin B. А., Gushcha S. G.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The authors used 192 white clinically healthy Wistar rats of outbred breeding weighing 180-200 g to conduct experimental studies to determine whether structural and functional parameters of the kidneys were related to normal (control group 1 – intact rats) and physiological course load (group 2) with natural mineral waters (MW) with a high content of organic matter (Corg). The use of this type of MW was due to the fact that the substances grouped under the concept of Corg have regulatory properties and can affect the functional activity of the kidneys. The study results showed that drinking by clinically healthy rats of the 2nd group of natural MWs with a high content of Corg compared with the control group changes the value of indicators of renal functional activity. In this case, the indicators of the structural organisation of the kidneys necessarily change. It allows us to state a close relationship between the indicators of functional and structural activity of the kidneys under physiological load conditions. This set of interrelated changes in the indicators of the organ's condition is defined in the literature as a structuralfunctional-metabolic continuum. Thus, the obtained results confirm the existence of such a phenomenon as one of the mechanisms of homeostasis maintenance.

Tags:

Bibliography:

1. Roumelioti ME, Glew RH, Khitan ZJ, Rondon-Berrios H, Argyropoulos CP, Malhotra D, et al. Fluid balance concepts in medicine: Principles and practice. World J Nephrol. 2018 Jan 6;7(1):1-28. DOI: 10.5527/wjn.v7.i1.1.
2. Gozhenko AI. Funktsionalno-metabolichnii kontinuum. Zhurnal NAMN Ukrainy. 2016;22(1):3-8. Dostupno: http://nbuv.gov.ua/UJRN/jnamnu_ 2016_22_1_2. [in Ukrainian].
3. Armstrong LE, Johnson EC. Water Intake, Water Balance, and the Elusive Daily Water Requirement. Nutrients. 2018;10(12):1928. DOI: https://doi. org/10.3390/nu10121928.
4. Hozhenko AI, Kravchuk AV, Nykytenko OP, Moskolenko OM, Sirman VM. Funktsionalnyi nyrkovyi rezerv. Odesa: Feniks; 2015. 182 s. Dostupno: https://nephrology.kiev.ua/wp-content/uploads/2012/05/Gozhenko-A.I.-Funktsionalnyj-pochechnyj-rezerv.pdf. [in Ukrainian].
5. Atherton JC. Regulation of fluid and electrolyte balance by the kidney. Anaesthesia & Intensive Care Medicine. 2006;7(7):227-233. DOI: https://doi.org/10.1053/j.mpaic.2006.04.002.
6. Stanhewicz AE, Kenney WL. Determinants of water and sodium intake and output. Nutrition Reviews. 2015;73(2/1):73-82. DOI: https:// doi.org/ 10.1093/nutrit/nuv033.
7. Tsimmernam YaS, Dimov AS. Scientific legacy of I.V. Davydovsky – philosophical foundations of general pathology. Clinical Medicine. 2016;94(8):565-574. DOI: 10.18821/0023-2149-2016-94-8-565-574.
8. Hozhenko AI, Hryshko YuM. Funktsionalno-metabolichnyi kontynuum: fiziolohiia i patolohiia. Poltava: TOV NVP «Ukrpromtorhservis»; 2020. 200 s. Dostupno: http://repository.pdmu.edu.ua/bitstream/123456789/14648/1/ Hryshko_monohrafiia.pdf. [in Ukrainian].
9. Olde Engberink RHG, van Oosten PJ, Weber T, Tabury К, Baatout S, Siew К, et al. The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps. NPJ Microgravity. 2023;9(1):29. DOI: https://doi.org/10.1038/s41526-023-00268-1.
10. Murray IV, Paolini MA. Histology, Kidney and Glomerulus [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan [updated 2023 Apr 17]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554544/.
11. Gushcha SG, Nasibullin ВА, Plakida АL, Kalinichenko VN, Tikhokhod LV, Mohylevska TV. Pathogenetic and sanogenetic mechanisms of the influence of mineral waters (siliconed and with increased organic substances) of different osmularity on the exposure of toxic nephritis. Journal of Biotechnology and Bioengineering. 2018;2(2):7-12. Available from: https://kurort.gov.ua/wp-content/uploads/2019/04/gusha_8. pdf.
12. Chagnac A, Zingerman B, Rozen-Zvi B, Herman-Edelstein M. Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity. Nephron. 2019;143(1):38-42. DOI: 10.1159/000499486.
13. Pavliuk NM, Hushcha SH, Badiuk NS. Vplyv zminy mahniievoho metabolizmu na Strukturno funktsionalnyi stan nyrok pry stresindukovanii endohennii intoksykatsii. Aktualni problemy transportnoi medytsyny. 2020;3(61):120-126. DOI: http://dx.doi.org/10.5281/zenodo.4081805. [in Ukrainian].
14. Jo SM, Nam J, Park SY, Park G, Kim BG, Jeong GH, et al. Effect of Mineral-Balanced Deep-Sea Water on Kidney Function and Renal Oxidative Stress Markers in Rats Fed a High-Salt Diet. Int J Mol Sci. 2021 Dec 14;22(24):13415. DOI: 10.3390/ijms222413415.
15. Gozhenko A, Badiuk N, Nasibullin B, Gushcha S, Gozhenko O, Vasyuk V, et al. The role of macronutrients in the implementation of the corrective effect of low-mineralized water in experimental metabolic syndrome. Rocz Panstw Zakl Hig. 2020;71(4):423-430. DOI: 10.32394/ rpzh.2020.0136.
16. Szabó І, Varga С. Finding possible pharmacological effects of identified organic compounds in medicinal waters (BTEX and phenolic compounds). Int J Biometeorol. 2020;64:989-995. DOI: https://doi.org/10.1007/s00484-019-01808-9.
17. Litopystsia VA. Unikalnist Truskavetskoi «Naftusi». Poltava: «Shvydkodruk»; 2012. Chastyna, Henez i mekhanizm dii «Naftusi» kurortu Truskavets; s. 72-77. [in Ukrainian].
18. Celso Gomes С, Rautureau М. Minerals latu sensu and Human Health. Benefts, Toxicity and Pathologies. Switzerland AG: Springer Nature; 2021. 668 р.
19. Kucherenko M, Nasibullin B, Gushcha S, Bobro E, Badiuk N, Glushchenko V, et al. The influence of natural mineral water on the structural and functional changes in the rat kidneys under urolithiasis modelling. Balneo Research Journal. 2020;11(4):477-480. DOI: 10.12680/ balneo.2020.382.
20. Shestopalov VM, Moiseeva NP, Ishhenko AP. Lechebnye mineral’nye vody tipa «Naftusja» Ukrainskih Karpat i Podol’ja. Chernovcy: Bukrek; 2013. 600 s.
21. Vagra C. Problems with classification of spa waters used in balneology. Health. 2010;2(11):1260-1263. DOI: 10.4236/health.2010.211187.
22. Dudchenko MA, Sorokina SI, Tretiak NH. Vykorystannia mineralnykh vod Boryslavskoho rehionu dlia reabilitatsii khvorykh. Svit medytsyny ta biolohii. 2017;4(62):191-194. DOI: 10.26724/2079-8334-2017-4-62-192-195. [in Ukrainian].
23. Hanzel1 А, Berényi1 К, Horváth К, Szendi К, Németh В, Varga С. Evidence for the therapeutic effect of the organic content in Szigetvár thermal water on osteoarthritis: a double-blind, randomized, controlled clinical trial. International Journal of Biometeorology. 2019;63:449- 458. DOI: https://doi.org/10.1007/s00484-019-01676-3.
24. Hrytsak MV, Badiuk NS, Popovych DV, Zhukov VA. Mineralni vody «Myroslava» i «Khrystyna. Torun: UMK; 2022: 214 s. Dostupno: https:// zenodo.org/records/6412511. [in Ukrainian].
25. Іvasіvka SV. Bіologіchno aktivnі rechovini vodi Naftusja, yh genezis ta mehanіzmi fіzіologіchnoi dіi. Kiev: Naukova dumka; 1997. 111 s. [in Ukrainian].
26. Babov KD, Nіkіpelova OM, Mokіenko AV, redaktori. Rol’ mіkrobіoti u formuvannі mіneral’nih prirodnih vod. Odesa; 2017. 240 s. [in Ukrainian].
27. Ivasivka SV, Popovych IL, Aksentiichuk BV, Bilas VR. Pryroda balneochynnykiv vody Naftusia i sut yii likuvalno-profilaktychnoi dii. Truskavets: Truskavetskurort; 1999. 125 s. [in Ukrainian].
28. Bilas VR, Popadynets’ OO, Flyunt ISS, Badiuk NS, Gushcha SG. Entropies of thymocytogram, splenocytogram, immunocytogram and leukocytogram in rats are regulated by sex and the neuroendocrine parameters while regulates immune parameters. Journal of Education, Health and Sport. 2020;10(7):266-288. DOI: http://dx.doi.org/10.12775/JEHS.2020.10.07.031.
29. Shestopalov VM, Moiseeva NP, redaktory. Moiseev AJu. Osobennosti himicheskogo sostava i bal’neologicheskogo primenenija mineral’nyh vod. K.: KIM; 2017. 464 s.
30. Ruzhylo SV, Zakalyak NR, Żukow X, Popovych DV. Comparative study of the attributive effects of fresh and canned Naftussya water. Journal of Education, Health and Sport. Online. 2023;13(4):142-149. DOI: 10.12775/JEHS.2023.13.04.015.
31. Gozhenko AІ, Hryshko YuM. Chronic stress and its metabolic support. Actual Problems of the Modern Medicine. 2019;4(68):123-129. DOI: 10.31718/2077-1096.19.4.123.
32. Dzyak GV, Kaplan PA. Kardiorenalnii sindrom: patofiziologiya, verifikatsiya, podkhodi k lecheniyu. Pochki. 2012;1:1-3. Available from: http://www.mif-ua.com/archive/article/32309.
33. MOZ Ukrayni. Nakaz MOZ Ukrayni vіd 28.09.2009 r. № 692 «Pro zatverdzhennja metodichnih rekomendacіj z metodіv doslіdzhen’ bіologіchnoi dіi prirodnih lіkuval’nih resursіv ta preformovanih lіkuval’nih zasobіv». Kyyiv: MOZ Ukrayni; Dostupno: http://old.moz.gov.ua/ ua/ portal/dn_20090928_692.html. [in Ukrainian].
34. MOZ Ukrayni. Nakaz Ministerstva okhorony zdorovʺya Ukrayiny vid 06.09.2003 r. № 243 «Pro zatverdzhennya Poryadku zdiysnennya medyko-biolohichnoyi otsinky yakosti ta tsinnosti pryrodnykh likuvalʹnykh resursiv, vyznachennya metodiv yikh vykorystannya». Kyyiv: MOZ Ukrayni; Dostupno: https://zakon.rada.gov.ua/laws/show/z0752-03#Text. [in Ukrainian].
35. Babov KD, Bezverkhniuk TM, Gushcha SH, Zabolotna IB, Kysylevska AIu, Koieva KhO, et al. Pryrodni likuvalni resursy: abetka dlia korystuvacha:informatsiino-analitychnyi dovidnyk. Derzhavna ustanova «Ukrainskyi naukovo-doslidnyi instytut medychnoi reabilitatsii ta kurortolohii MOZ Ukrainy». Odesa: «Polihraf»; 2021. 76 s. Dostupno: https://kurort.gov.ua/wp-content/uploads/2016/11/dovidnyk_plr_sajt. pdf. [in Ukrainian].

Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 4, 171, 250-259 pages, index UDC 616.61-092.9:615.327.03

DOI:

10.29254/2077-4214-2023-4-171-250-259