Khramenko N. I.

COMPARATIVE CHARACTERISTICS OF REGIONAL HEMODYNAMICS IN OPTIC NERVE NEURITIS AND ANTERIOR ISCHEMIC OPTIC NERVE NEUROPATHY IN ACUTE AND CHRONIC COURSE

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About the author:

Khramenko N. I.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Anterior ischaemic optic neuropathy (AION) and optic neuritis (papilledema) (ON) are the most common causes of unilateral optic disc oedema. They often have similar clinical profiles and can be difficult to differentiate by clinical signs at initial presentation. Therefore, it is important to identify markers for the differential diagnosis of these diseases. Since regional hemodynamics is involved in the pathogenesis of these diseases, it is important to study the features of its state and compare the regional hemodynamic parameters of the eye obtained by rheo-ophthalmography and the brain by rheoencephalography in patients with ON and AION in the acute and chronic course of the disease to determine the diagnostic markers. In the present study, groups of patients with acute idiopathic ON, papillitis and its consequences (34 people (48 eyes)) and patients with acute and chronic AION (53 people (96 eyes)) were examined by computer rheography. The dependence of such indicators of ocular haemodynamics on the diagnostic factor as the index of volumetric pulse blood filling of the eye, the tone of large intraocular vessels, small intraocular vessels, and the rate of volumetric blood filling of the eye was determined. Among the indicators of cerebral haemodynamics, a diagnostically significant difference was observed in the tone of large and small calibre vessels, which were higher in patients with AION than in patients with ON. It was proposed to use the index of ocular blood flow RQ, the rate of ocular pulse blood flow V (ohm/s), and the index of large vessel tone α1/T (%) for the differential diagnosis of such optic neuropathies as ON and AION in the acute course of the disease.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 3, 170, 291-304 pages, index UDC 617.731-002:612.019:612.13:616-036.1

DOI:

10.29254/2077-4214-2023-3-170-291-304