Maslak V. I., Kalinichenko O. O., Okhmat O. A., Kotlyar М. М., Iungin O. S.
ANTIBIOFILM EFFECT OF COLLAGEN-BASED MATERIAL DEVELOPED FOR WOUND DRESSING
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About the author:
Maslak V. I., Kalinichenko O. O., Okhmat O. A., Kotlyar М. М., Iungin O. S.
Heading:
CLINICAL AND EXPERIMENTAL MEDICINE
Type of article:
Scientific article
Annotation:
The ongoing war in Ukraine and the urgent need to equip military personnel with advanced medical supplies has spurred the exploration of innovative next-generation materials for treating wounds. These materials must possess potent antibacterial properties and are likely to be built upon a biopolymeric base. The surplus collagen-rich waste generated by the leather industry offers an opportunity for collagen extraction and repurposing. Collagen, a biopolymer with widespread applications in cosmetics and medicine, plays a crucial role in wound healing products. It acts not only as a protective barrier against external contaminants but also stimulates fibroblast production and acts as a carrier for antimicrobial agents. The aim of our study was to test antimicrobial effectiveness against opportunistic bacteria of collagen-based material obtained from leather industry waste developed for wound dressing. We adapted a sterilization procedure based on a chloroform protocol. Utilizing chloroform sterilization for collagen preparation demonstrated successful reduction in cell attachment for the studied bacterial strains, suggesting a potential anti-fouling approach for preparing wound dressing materials. This innovative collagen-based wound dressing, boasting antimicrobial and antibiofilm properties, holds promise for future clinical studies and potential utilization in wound treatment.
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Publication of the article:
«Bulletin of problems biology and medicine», 2023 Issue 3, 170, 226-229 pages, index UDC 571.69+675, 616-001.4/.6
