Panchenko Yu. M., Drozdovska S. B.

THE PARTICIPATION OF IRISIN IN THE MECHANISMS OF WEIGHT LOSS IN OBESITY

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About the author:

Panchenko Yu. M., Drozdovska S. B.

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LITERATURE REVIEWS

Type of article:

Scientific article

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During muscle contractions, several biologically active substances are produced, which conduct communication between various organs, systems and tissues following the body's metabolic needs. Irisin belongs to the list of substances called myokines. It causes various effects on the metabolism, taking part in implementing the health-improving impact of physical exercises, which determines the interest in its study by researchers in the field of physical culture. The main effect of irisin is the activation of converting white fat into brown fat in adipocytes, followed by an increase in mitochondrial lipid oxidation. Despite a wide range of research, the main regularities of the action of irisin have not yet been systematized. In this review, we analyze the mechanisms and features of irisin's participation in losing body weight. The study aims to establish the molecular mechanisms and regularities of the participation of the myokine irisin in losing body weight of obese women during health fitness classes and the possibility of using the level of circulating irisin as a marker of the effectiveness of training loads using the analysis of scientific literature. It has been established that in the studies, there is a high heterogeneity of indicators of mRNA and protein irisin levels in tissues and blood in response to physical exertion. Factors that affect the level of irisin include the type of tissue, the type of object, the method of measurement, the directionality, intensity and duration of physical exertion. Research on the duration and nature of physical activity that causes probable changes in the increase of irisin, and therefore the effect on thermogenesis, additional interventions that can be used to control its level, will contribute to the development of programs of health-improving physical activities aimed at normalizing body weight.

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Bibliography:

1. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88(4):1379-406.
2. Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology. 2012;8(8):457-65.
3. Whitham M, Febbraio MA. The ever-expanding myokinome: discovery challenges and therapeutic implications. Nat Rev Drug Discov. 2016;15(10):719-29.
4. Pedersen BK. Physical activity and muscle–brain crosstalk. Nature Reviews Endocrinology. 2019;15(7):383-92.
5. Balakrishnan R, Thurmond DC. Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance. Int J Mol Sci. 2022;23(9):4636. DOI: 10.3390/ijms23094636.
6. Grannell A, Kokkinos A, le Roux CW. Myokines in Appetite Control and Energy Balance. Muscles. 2022;1(1):26-47.
7. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-8.
8. Waseem R, Shamsi A, Mohammad T, Hassan MI, Kazim SN, Chaudhary AA, et al. FNDC5/Irisin: Physiology and Pathophysiology. Molecules. 2022;27(3):1118. DOI: 10.3390/molecules27031118.
9. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013;98(4):E769-78.
10. Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes. 2014;63(2):514-25.
11. Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, et al. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Cell. 2018;175(7):1756-68.e17.
12. Elsen M, Raschke S, Eckel J. Browning of white fat: does irisin play a role in humans? J Endocrinol. 2014;222(1):R25-38.
13. Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, et al. The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. Febs j. 2014;281(3):739-49.
14. Eckel J, editor. The Cellular Secretome and Organ Crosstalk: Academic Press; 2018. Chapter 3, Skeletal Muscle: A Novel Secretory Organ; p. 65-90.
15. D’Amuri A, Sanz JM, Lazzer S, Pišot R, Šimunič B, Biolo G, et al. Irisin Attenuates Muscle Impairment during Bed Rest through MuscleAdipose Tissue Crosstalk. Biology. 2022;11(7):999.
16. Maalouf G-E, El Khoury D. Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent. Journal of Obesity. 2019;2019:6561726.
17. Li J, Yi X, Li T, Yao T, Li D, Hu G, et al. Effects of exercise and dietary intervention on muscle, adipose tissue, and blood IRISIN levels in obese male mice and their relationship with the beigeization of white adipose tissue. Endocr Connect. 2022;11(3):e210625. DOI: 10.1530/ EC-21-0625.
18. Chou TJ, Lu CW, Lin LY, Hsu YJ, Huang CC, Huang KC. Proteomic Analysis of Skeletal Muscle and White Adipose Tissue after Aerobic Exercise Training in High Fat Diet Induced Obese Mice. Int J Mol Sci. 2023;24(6):5743. DOI: 10.3390/ijms24065743.
19. Cho C, Ji M, Cho E, Yi S, Kim JG, Lee S. Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice. J Physiol Sci. 2023;73(1):6.
20. Gheit R, Younis RL, El-Saka MH, Emam MN, Soliman NA, El-Sayed RM, et al. Irisin improves adiposity and exercise tolerance in a rat model of postmenopausal obesity through enhancing adipo-myocyte thermogenesis. J Physiol Biochem. 2022;78(4):897-913.
21. Archundia-Herrera C, Macias-Cervantes M, Ruiz-Muñoz B, Vargas-Ortiz K, Kornhauser C, Perez-Vazquez V. Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetol Metab Syndr. 2017;9:101.
22. Yuksel Ozgor B, Demiral I, Zeybek U, Celik F, Buyru F, Yeh J, et al. Effects of Irisin Compared with Exercise on Specific Metabolic and Obesity Parameters in Female Mice with Obesity. Metabolic Syndrome and Related Disorders. 2020;18(3):141-5.
23. Amaro Andrade P, Souza Silveira BK, Corrêa Rodrigues A, Oliveira da Silva FM, Barbosa Rosa CO, Gonçalves Alfenas RC. Effect of exercise on concentrations of irisin in overweight individuals: A systematic review. Science & Sports. 2018;33(2):80-9.
24. Colpitts BH, Rioux BV, Eadie AL, Brunt KR, Sénéchal M. Irisin response to acute moderate intensity exercise and high intensity interval training in youth of different obesity statuses: A randomized crossover trial. Physiol Rep. 2022;10(4):e15198.
25. Bernal Rivas C, Llamunao Tropa Á, Reyes Barría A, Halabi D, Pavicic F, Ehrenfeld P, et al. Effects of exercise on irisin in subjects with overweight or obesity. A systematic review of clinical studies. Nutr Hosp. 2022;39(6):1389-96.
26. Moienneia N, Attarzadeh Hosseini SR. Acute and chronic responses of metabolic myokine to different intensities of exercise in sedentary young women. Obesity Medicine. 2016;1:15-20.
27. Merawati D, Sugiharto, Susanto H, Taufiq A, Pranoto A, Amelia D, et al. Dynamic of irisin secretion change after moderate-intensity chronic physical exercise on obese female. J Basic Clin Physiol Pharmacol. 2023;34(4):539-547.
28. Rashid FA, Abbas HJ, Naser NA, Addai Ali H. Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men. ScientificWorldJournal. 2020;2020:1897027. DOI: 10.1155/2020/ 1897027.
29. Taherzadeh S, Rasoulian B, Khaleghi M, Rashidipour M, Mogharnasi M, Kaeidi A. Anti-obesity effects of aerobic exercise along with Rosa canina seed extract supplementation in rats: The role of irisin and adipolin. Obes Res Clin Pract. 2023;17(3):218-25.
30. Fu Y, Gao Y, Wang L, Guo CJ, Liu YX, Yu L. Effects of alternate-day modified fasting combined exercise on fat reducing and the FNDC5/ Irisin-UCP1 pathway. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022;38(5):577-83.
31. Xue Y, Hu S, Chen C, He J, Sun J, Jin Y, et al. Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice. International Journal of Biological Sciences. 2022;18(2):572-84.
32. Mattson MP. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab. 2012;16(6):706- 22.
33. Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, et al. Exercise induces hippocampal BDNF through a PGC-1α/ FNDC5 pathway. Cell Metab. 2013;18(5):649-59.
34. Townsend LK, Steinberg GR. AMPK and the Endocrine Control of Metabolism. Endocr Rev. 2023;00:1-24 DOI: 10.1210/endrev/bnad012.

Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 3, 170, 71-80 pages, index UDC 796.012.12.071:616.127+616-007.61

DOI:

10.29254/2077-4214-2023-3-170-71-80