MORPHOFUNCTIONAL CHARACTERISTICS OF THE CARDIOPROTECTIVE PROPERTIES OF SUCCINIC ACID, SODIUM OXYBUTYRATE AND QUERCETIN IN THE CORRECTION OF EPINEPHRINE MYOCARDIODYSTROPHY IN AN EXPERIMENT

  2. 2023
  3. MORPHOFUNCTIONAL CHARACTERISTICS OF THE CARDIOPROTECTIVE PROPERTIES OF SUCCINIC ACID, SODIUM OXYBUTYRATE AND QUERCETIN IN THE CORRECTION OF EPINEPHRINE MYOCARDIODYSTROPHY IN AN EXPERIMENT

Herasymiuk K. O.

MORPHOFUNCTIONAL CHARACTERISTICS OF THE CARDIOPROTECTIVE PROPERTIES OF SUCCINIC ACID, SODIUM OXYBUTYRATE AND QUERCETIN IN THE CORRECTION OF EPINEPHRINE MYOCARDIODYSTROPHY IN AN EXPERIMENT

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About the author:

Herasymiuk K. O.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

In connection with the prevalence and continuous progression of cardiovascular pathology in recent years, many clinicians and scientists have been directed to the search for effective means of preventing irreversible necrobiotic processes in the myocardium, including during anesthesiological support of cardiac surgical operations. Therefore, the conducted research aimed to give a morpho-functional justification of the cardioprotective properties of succinic acid, sodium oxybutyrate and quercetin to correct experimental heart failure. Experiments were carried out on white laboratory rats simulating adrenaline-induced myocardial dystrophy. Medication correction was carried out by intragastric administration of each specified drug separately. The exposure for introduction was 15 minutes from the beginning of the simulation of myocardial dystrophy. Histological studies were performed 2 and 24 hours after the injection of adrenaline. The use of these drugs (succinic acid, sodium oxybutyrate and quercetin) for preventing and correcting dystrophic changes in the myocardium is based on their common antihypoxic, cardioprotective and metabolic properties. The obtained morphological data indicate a positive effect of their application both in the early (after 2 hours from the experiment) and in the long term (after 24 hours from the start), which is fully consistent with the results of other studies. All this makes it possible to recommend them for use in clinical practice. At the same time, slightly more pronounced angioprotective properties were noted in quercetin compared to succinic acid and sodium oxybutyrate.

Tags:

arteries, cardiomyocytes, correction, myocardiodystrophy, veins

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Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 2, 169, 360-367 pages, index UDC 616.127-007.17:577.175.522]-085.22-092.9

DOI:

10.29254/2077-4214-2023-2-169-360-367

2023 Issue 2, 169
arteries cardiomyocytes correction myocardiodystrophy veins
29.06.2023
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