THE CONCEPT OF NITRO-OXIDATIVE STRESS IN ACUTE GENERALIZED PERITONITIS ON THE BACKGROUND OF OBESITY IN EXPERIMENT

  2. 2023
  3. THE CONCEPT OF NITRO-OXIDATIVE STRESS IN ACUTE GENERALIZED PERITONITIS ON THE BACKGROUND OF OBESITY IN EXPERIMENT

Malevych N. M., Klishch I. M.

THE CONCEPT OF NITRO-OXIDATIVE STRESS IN ACUTE GENERALIZED PERITONITIS ON THE BACKGROUND OF OBESITY IN EXPERIMENT

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About the author:

Malevych N. M., Klishch I. M.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Globally, acute generalized peritonitis (AGP) is a common medical and surgical emergency, which is a major cause of mortality, and the number of obese populations is constantly increasing every year. Aim was to study the state of the indicators of the nitric oxide system in the body of experimental animals with simulated AGP against the background of obesity and compare them with groups of obese animals and with animals with AGP. 64 white Wistar rats were used, which were divided into three groups: the main group – 24 animals with AGP simulation on the background of obesity; comparison group – 8 animals with obesity simulation; another comparison group – 24 animals with GPP modeling; control – 8 intact animals. AGP was modeled by injecting 10 % filtered fecal suspension into the abdominal cavity. Obesity was simulated using a high-calorie diet. On the 1st day, the level of NOx metabolites in the blood serum of the group of animals with AGP on the background of obesity was 9 % significantly higher than that of the group of animals with isolated GPP, on the 3rd day – by 8 %, and on the 7th day – by 7 %, respectively (р<0,05). Comparing the indicators of NO-synthase activity in the liver of the rats of the main group and the comparison group, we obtained higher indicators in the animals of the AGP group and the background of obesity during all periods of the experiment: on the 1st day – by 16 %, on the 3rd day – by 14 %, and on the 7th day – by 13 % (р<0,05). The mechanisms of nitrooxidative stress are significantly increased in animals with AGP against the background of obesity during all periods of the experiment, which is confirmed by statistically significantly higher levels of NOsynthase in the liver and the content of nitrates and nitrites in blood serum compared to animals with isolated obesity or animals with AGP

Tags:

acute generalized peritonitis, nitro-oxidative stress, obesity

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Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 2, 169, 277-281 pages, index UDC 616.381-002.1:616-056.52-06:612.017]-092.9

DOI:

10.29254/2077-4214-2023-2-169-277-281

2023 Issue 2, 169
acute generalized peritonitis nitro-oxidative stress obesity
29.06.2023
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